- mir-29 microRNA precursor
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mir-29 microRNA precursor 
Predicted secondary structure and sequence conservation of mir-29 Identifiers Symbol mir-29 Rfam RF00074 miRBase MI0000087 miRBase family MIPF0000009 Other data RNA type Gene; miRNA Domain(s) Eukaryota GO 0035195 0035068 SO 0001244 miR-29 microRNA precursor is a small non-coding RNA that is involved in regulating gene expression.[1] This microRNA (miRNA) has been predicted or confirmed in a wide range of species (MIPF0000009). Animal miRNAs are transcribed as an approximately 70 nucleotide precursor and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 3' arm of the precursor RNA. The products are thought to have regulatory roles through complementarity to mRNA.
Targets of miR-29
It has been shown that miR-29 regulates the level of the Mcl-1 protein.[2] Mcl-1 is an anti-apoptotic member of the Bcl-2 family of proteins.
It has been shown that miR-29 regulates the level of Tcl1 protein.[3] The Tcl1 (T-cell leukemia/lymphoma 1) oncogene found to be disrupted in many T-cell leukemias.
It has been shown that miR-29 directly target both DNMT3A and DNMT-3B which DNA methyltransferase proteins frequently upregulated in lung cancer.[4]
References
- ^ Ambros, V (2001). "microRNAs: tiny regulators with great potential". Cell 107 (7): 823–826. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
- ^ Mott JL, Kobayashi S, Bronk SF, Gores GJ (2007). "mir-29 regulates Mcl-1 protein expression and apoptosis". Oncogene 26 (42): 6133. doi:10.1038/sj.onc.1210436. PMC 2432524. PMID 17404574. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2432524.
- ^ Pekarsky Y, Santanam U, Cimmino A, et al. (2006). "Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181". Cancer Res. 66 (24): 11590–3. doi:10.1158/0008-5472.CAN-06-3613. PMID 17178851.
- ^ Fabbri M, Garzon R, Cimmino A, et al. (2007). "MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B". Proc. Natl. Acad. Sci. U.S.A. 104 (40): 15805–10. doi:10.1073/pnas.0707628104. PMC 2000384. PMID 17890317. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2000384.
External links
miRNA precursor families 1-100 101-200 201+ Other Categories:- MicroRNA
- Molecular and cellular biology stubs
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