Mir-181 microRNA precursor

miR-181 microRNA precursor is a small non-coding RNA molecules. MicroRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide mature product. In this case the mature sequence comes from the 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to target mRNAs. miR-181 which has been predicted or experimentally confirmed in a wide number of vertebrate species ( [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000007 MIPF0000007] ). It has been shown that miR-181 is preferentially expressed in the B-lymphoid cells of mouse bone marrow,cite journal | author = Chen CZ, Li L, Lodish HF, Bartel DP | title = MicroRNAs modulate hematopoietic lineage differentiation | journal = Science | volume = 303 | issue = 5654 | pages = 83–6 | year = 2004 | pmid = 14657504 | doi = 10.1126/science.1091903 | issn = ] but also in the retina and brain.cite journal | author = Ryan DG, Oliveira-Fernandes M, Lavker RM | title = MicroRNAs of the mammalian eye display distinct and overlapping tissue specificity | journal = Mol. Vis. | volume = 12 | issue = | pages = 1175–84 | year = 2006 | pmid = 17102797 | doi = | issn = ]

Targets of miR-181

* Naguibneva "et al". showed that miR-181 targets the homeobox protein Hox-A11 and participates in establishing muscle tissue.cite journal | author = Naguibneva I, Ameyar-Zazoua M, Polesskaya A, "et al" | title = The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation | journal = Nat. Cell Biol. | volume = 8 | issue = 3 | pages = 278–84 | year = 2006 | pmid = 16489342 | doi = 10.1038/ncb1373 | issn = ]
* Pekarsky "et al". showed that the Tcl1 oncogene is a target of miR-181.cite journal | author = Pekarsky Y, Santanam U, Cimmino A, "et al" | title = Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181 | journal = Cancer Res. | volume = 66 | issue = 24 | pages = 11590–3 | year = 2006 | pmid = 17178851 | doi = 10.1158/0008-5472.CAN-06-3613 | issn = ]

References

* [5] cite journal | last = Ambros | first = V | year = 2001 | title = microRNAs: tiny regulators with great potential | journal = Cell | volume = 107 | pages = 823–826 | pmid = 11779458 | doi = 10.1016/S0092-8674(01)00616-X
* [6] cite journal | last = Lagos-Quintana | first = M | coauthors = Rauhut R, Meyer J, Borkhardt A, Tuschl T | year = 2003 | title = New microRNAs from mouse and human | journal = RNA | volume = 9 | pages = 175–179 | pmid = 12554859 | doi = 10.1261/rna.2146903

External links

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* [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000007 MIPF0000007]