mir-26 microRNA precursor family

mir-26 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-26
Identifiers
Symbol	mir-26
Rfam	RF00244
miRBase	MI0000083
miRBase family	MIPF0000043
Other data
RNA type	Gene; miRNA
Domain(s)	Eukaryota
GO	0035195 0035068
SO	0001244

The miR-26 microRNA precursor is a small non-coding RNA that is involved in regulating gene expression. miR-26 appears to be a vertebrate specific microRNA^[1][2] and has now been predicted or experimentally validated in many vertebrate species (MIPF0000043). In this microRNA the mature sequence is excised from the 5' arm of the hairpin. miR-26 has been shown to be expressed in neural tissue.^[3] It has also been suggested that miR-26 is involved in response to low oxygen levels.^[4]

References

1. ^ Lagos-Quintana, M; Rauhut R, Lendeckel W, Tuschl T (2001). "Identification of novel genes coding for small expressed RNAs". Science 294 (5543): 853–858. doi:10.1126/science.1064921. PMID 11679670. 
2. ^ Lagos-Quintana, M; Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T (2002). "Identification of tissue-specific microRNAs from mouse". Curr Biol 12 (9): 735–739. doi:10.1016/S0960-9822(02)00809-6. PMID 12007417. 
3. ^ Smirnova L, Gräfe A, Seiler A, Schumacher S, Nitsch R, Wulczyn FG (2005). "Regulation of miRNA expression during neural cell specification". Eur. J. Neurosci. 21 (6): 1469–77. doi:10.1111/j.1460-9568.2005.03978.x. PMID 15845075. 
4. ^ Kulshreshtha R, Ferracin M, Wojcik SE, et al. (2007). "A microRNA signature of hypoxia". Mol. Cell. Biol. 27 (5): 1859–67. doi:10.1128/MCB.01395-06. PMC 1820461. PMID 17194750. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1820461. 

External links

• Rfam page for mir-26 microRNA precursor family
• MIPF0000043