mir-46/mir-47/mir-281 microRNA precursor family

mir-46/mir-47/mir-281 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-46
Identifiers
Symbol	mir-46
Rfam	RF00249
miRBase	MI0000017
miRBase family	MIPF0000087
Other data
RNA type	Gene; miRNA
Domain(s)	Eukaryota
GO	0035195 0035068
SO	0001244

In molecular biology, mir-46 (MI0000017) and mir-47 (MI0000018) are microRNA expressed in C. elegans from related hairpin precursor sequences.^[1] The predicted hairpin precursor sequences for Drosophila mir-281 (MI0000366, MI0000370)^[2][3] are also related and, hence, belong to this family. The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation; their extents are not known. In this case, the mature sequences are expressed from the 3' arms of the hairpin precursors.

References

1. ^ Lau, NC; Lim LP, Weinstein EG, Bartel DP (2001). "An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans". Science 294 (5543): 858–862. doi:10.1126/science.1065062. PMID 11679671. 
2. ^ Lai, EC; Tomancak P, Williams RW, Rubin GM (2003). "Computational identification of Drosophila microRNA genes". Genome Biol 4 (7): R42–. doi:10.1186/gb-2003-4-7-r42. PMC 193629. PMID 12844358. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=193629. 
3. ^ Aravin, AA; Lagos-Quintana M, Yalcin A, Zavolan M, Marks D, Snyder B, Gaasterland T, Meyer J, Tuschl T (2003). "The small RNA profile during Drosophila melanogaster development". Dev Cell 5 (2): 337–350. doi:10.1016/S1534-5807(03)00228-4. PMID 12919683. 

External links

• Rfam page for mir-46/mir-47/mir-281 microRNA precursor family
• MI0000017
• MI0000018
• MI0000366
• MI0000370