mir-101 microRNA precursor family

mir-101 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-101
Identifiers
Symbol	mir-101
Rfam	RF00253
miRBase	MI0000103
miRBase family	MIPF0000046
Other data
RNA type	Gene; miRNA
Domain(s)	Eukaryota
GO	0035195 0035068
SO	0001244

miR-101 microRNA precursor is a small non-coding RNA that regulates gene expression. Expression of miR-101 has been validated in both human (MI0000103, MI0000739)^[1] and mouse (MI0000148).^[2] This microRNA appears to be specific to the vertebrates and has now been predicted or confirmed in a wide range of vertebrate species (MIPF0000046). The precursor microRNA is a stem-loop structure of about 70 nucleotides in length that is processed by the Dicer enzyme to form the 21-24 nucleotide mature microRNA. In this case the mature sequence is excised from the 3' arm of the hairpin.

References

1. ^ Mourelatos, Z; Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev 16 (6): 720–728. doi:10.1101/gad.974702. PMC 155365. PMID 11914277. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=155365. 
2. ^ Lagos-Quintana, M; Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T (2002). "Identification of tissue-specific microRNAs from mouse". Curr Biol 12 (9): 735–739. doi:10.1016/S0960-9822(02)00809-6. PMID 12007417. 

External links

• Rfam page for mir-101 microRNA precursor family
• miRBase family MIPF0000046