Diacylglycerol lipase

Diacylglycerol lipase
diacylglycerol lipase, alpha
Identifiers
Symbol DAGLA
Alt. symbols C11orf11
Entrez 747
HUGO 1165
RefSeq NM_006133
UniProt Q9Y4D2
Other data
EC number 3.1.1.-
Locus Chr. 11 q12.3
diacylglycerol lipase, beta
Identifiers
Symbol DAGLB
Entrez 221955
HUGO 28923
RefSeq NM_139179
UniProt Q8NCG7
Other data
EC number 3.1.1.-
Locus Chr. 7 p22.1

Diacylglycerol lipase, also known as DAG lipase, DAGL or DGL, is a key enzyme in the biosynthesis of the endocannabinoid 2-arachidonoylglycerol.[1] It catalyzes the hydrolysis of diacylglycerol, releasing a free fatty acid and monoacylglycerol.

Two separate genes encoding DGL enzymes have been cloned, termed DGLα (DAGLA) and DGLβ (DAGLB), that share 33% sequence identity.

Inhibitors

The enzyme has been described to be inhibited selectively by two agents, RHC80267 and tetrahydrolipstatin.

References

  1. ^ Bisogno T, Howell F, Williams G, et al. (November 2003). "Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain". J. Cell Biol. 163 (3): 463–8. doi:10.1083/jcb.200305129. PMC 2173631. PMID 14610053. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173631. 

External links

v · d · eHydrolase: esterases (EC 3.1)
3.1.1: Carboxylic ester hydrolases
3.1.2: Thioesterase
3.1.3: Phosphatase
3.1.4: Phosphodiesterase
3.1.6: Sulfatase
Nuclease (includes
deoxyribonuclease and
ribonuclease)
RNase III · RNase H (1, 2A, 2B, 2C) · RNase P · RNase A (1, 2, 3, 4/5) · RNase T1 · RNA-induced silencing complex
either deoxy- or ribo-
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
v · Metabolism: lipid metabolism - eicosanoid metabolism enzymes
Precursor

Phospholipase A2

Phospholipase C · Diacylglycerol lipase
Prostanoids
Leukotrienes
Ungrouped

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

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