Leukotriene C4 synthase

Leukotriene C4 synthase, also known as LTC4S, is a human gene.cite web | title = Entrez Gene: LTC4S leukotriene C4 synthase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4056| accessdate = ]

The protein encoded by this gene, LTC4S (or glutathione S-transferase II) is an enzyme which converts leukotriene A4 and glutathione to create leukotriene C4. This is a member of MAPEG family of transmembrane proteins.

A trimer of Leukotriene C4 synthase is localized on the outer nuclear membrane and endoplasmic reticulum where it forms a complex with 5-Lipoxygenase activating protein. This protein is remotely related to microsomal glutathione S-transferase.

PBB_Summary
section_title =
summary_text = The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum.cite web | title = Entrez Gene: LTC4S leukotriene C4 synthase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4056| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Penrose JF |title=LTC4 synthase. Enzymology, biochemistry, and molecular characterization. |journal=Clinical reviews in allergy & immunology |volume=17 |issue= 1-2 |pages= 133–52 |year= 1999 |pmid= 10436863 |doi=
*cite journal | author=Penrose JF, Austen KF |title=The biochemical, molecular, and genomic aspects of leukotriene C4 synthase. |journal=Proc. Assoc. Am. Physicians |volume=111 |issue= 6 |pages= 537–46 |year= 2000 |pmid= 10591082 |doi=
*cite journal | author=Jakobsson PJ, Morgenstern R, Mancini J, "et al." |title=Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily. |journal=Am. J. Respir. Crit. Care Med. |volume=161 |issue= 2 Pt 2 |pages= S20–4 |year= 2000 |pmid= 10673221 |doi=
*cite journal | author=Bigby TD |title=The leukotriene C(4) synthase gene and asthma. |journal=Am. J. Respir. Cell Mol. Biol. |volume=23 |issue= 3 |pages= 273–6 |year= 2000 |pmid= 10970815 |doi=
*cite journal | author=Penrose JF, Gagnon L, Goppelt-Struebe M, "et al." |title=Purification of human leukotriene C4 synthase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 23 |pages= 11603–6 |year= 1993 |pmid= 1454853 |doi=
*cite journal | author=Nicholson DW, Ali A, Klemba MW, "et al." |title=Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells. |journal=J. Biol. Chem. |volume=267 |issue= 25 |pages= 17849–57 |year= 1992 |pmid= 1517222 |doi=
*cite journal | author=Penrose JF, Spector J, Lam BK, "et al." |title=Purification of human lung leukotriene C4 synthase and preparation of a polyclonal antibody. |journal=Am. J. Respir. Crit. Care Med. |volume=152 |issue= 1 |pages= 283–9 |year= 1995 |pmid= 7599836 |doi=
*cite journal | author=Söderström M, Morgenstern R, Hammarström S |title=Protein-protein interaction affinity chromatography of leukotriene C4 synthase. |journal=Protein Expr. Purif. |volume=6 |issue= 3 |pages= 352–6 |year= 1995 |pmid= 7663172 |doi= 10.1006/prep.1995.1046
*cite journal | author=Welsch DJ, Creely DP, Hauser SD, "et al." |title=Molecular cloning and expression of human leukotriene-C4 synthase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 21 |pages= 9745–9 |year= 1994 |pmid= 7937884 |doi=
*cite journal | author=Lam BK, Penrose JF, Freeman GJ, Austen KF |title=Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 16 |pages= 7663–7 |year= 1994 |pmid= 8052639 |doi=
*cite journal | author=Nicholson DW, Ali A, Vaillancourt JP, "et al." |title=Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 5 |pages= 2015–9 |year= 1993 |pmid= 8446623 |doi=
*cite journal | author=Penrose JF, Spector J, Baldasaro M, "et al." |title=Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35. |journal=J. Biol. Chem. |volume=271 |issue= 19 |pages= 11356–61 |year= 1996 |pmid= 8626689 |doi=
*cite journal | author=Bigby TD, Hodulik CR, Arden KC, Fu L |title=Molecular cloning of the human leukotriene C4 synthase gene and assignment to chromosome 5q35. |journal=Mol. Med. |volume=2 |issue= 5 |pages= 637–46 |year= 1997 |pmid= 8898379 |doi=
*cite journal | author=Scoggan KA, Jakobsson PJ, Ford-Hutchinson AW |title=Production of leukotriene C4 in different human tissues is attributable to distinct membrane bound biosynthetic enzymes. |journal=J. Biol. Chem. |volume=272 |issue= 15 |pages= 10182–7 |year= 1997 |pmid= 9092565 |doi=
*cite journal | author=Sala A, Folco G, Henson PM, Murphy RC |title=Pharmacological modulation of human platelet leukotriene C4-synthase. |journal=Biochem. Pharmacol. |volume=53 |issue= 6 |pages= 905–8 |year= 1997 |pmid= 9113110 |doi=
*cite journal | author=Spanbroek R, Stark HJ, Janssen-Timmen U, "et al." |title=5-Lipoxygenase expression in Langerhans cells of normal human epidermis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 2 |pages= 663–8 |year= 1998 |pmid= 9435249 |doi=

External links

UMichOPM|families|superfamily|199 - Eicosanoid and Glutathione metabolism protein family (MAPEG)

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