Arachidonate 12-lipoxygenase
- Arachidonate 12-lipoxygenase
In enzymology, an arachidonate 12-lipoxygenase (EC number|1.13.11.31) is an enzyme that catalyzes the chemical reaction
:arachidonate + O2 (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
Thus, the two substrates of this enzyme are arachidonate and O2, whereas its product is (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.
This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is arachidonate:oxygen 12-oxidoreductase. Other names in common use include Delta12-lipoxygenase, 12-lipoxygenase, 12Delta-lipoxygenase, C-12 lipoxygenase, 12S-lipoxygenase, leukotriene A4 synthase, and LTA4 synthase. This enzyme participates in arachidonic acid metabolism. At least one compound, 3-methoxytropolone is known to inhibit this enzyme.
References
*
*
*
External links
::"The CAS registry number for this enzyme class is CAS registry|82391-43-3."
Gene Ontology (GO) codes
Wikimedia Foundation.
2010.
Look at other dictionaries:
Arachidonate 5-lipoxygenase — (5 lipoxygenase, 5 LO or Alox5) is a human enzyme, member of the lipoxygenase family. It transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases.ubstrates and productsEFA substrates and… … Wikipedia
Arachidonate 15-lipoxygenase — In enzymology, an arachidonate 15 lipoxygenase (EC number|1.13.11.33) is an enzyme that catalyzes the chemical reaction:arachidonate + O2 ightleftharpoons (5Z,8Z,11Z,13E) (15S) 15 hydroperoxyicosa 5,8,11,13 tetraenoateThus, the two substrates of… … Wikipedia
Arachidonate 8-lipoxygenase — In enzymology, an arachidonate 8 lipoxygenase (EC number|1.13.11.40) is an enzyme that catalyzes the chemical reaction:arachidonate + O2 ightleftharpoons (5Z,9E,11Z,14Z) (8R) 8 hydroperoxyicosa 5,9,11,14 tetraenoateThus, the two substrates of… … Wikipedia
arachidonate 5-lipoxygenase — arach·i·don·ate 5 lip·oxy·gen·ase (ə rak″ĭ donґāt lĭ pokґsə jən ās) [EC 1.13.11.34] an enzyme of the oxidoreductase class that catalyzes the oxidation of arachidonate at the 5 position to form 5… … Medical dictionary
arachidonate 12-lipoxygenase — arach·i·don·ate 12 lip·oxy·gen·ase (ə rakґĭ don″āt lĭ pokґsə jən ās) [EC 1.13.11.31] an enzyme of the oxidoreductase class that catalyzes the oxidation of arachidonate at the 12 position to form 12… … Medical dictionary
arachidonate 15-lipoxygenase — arach·i·don·ate 15 lip·oxy·ge·nase (ə rakґĭ donґāt lĭ pokґsə jən ās) [EC 1.13.11.33] an enzyme of the oxidoreductase class that catalyzes the oxidation of arachidonate at the 15 position to form 15… … Medical dictionary
Lipoxygenase — Pfam box Symbol = Lipoxygenase Name = width =220 caption = Arachidonate 15 Lipoxygenase Pfam= PF00305 InterPro= IPR013819 SMART= PROSITE = PDOC00077 SCOP = 2sbl TCDB = OPM family= 87 OPM protein= 1zq4 PDB=PDB3|1y4kA:155 823 PDB3|2sblB:155 823… … Wikipedia
Lipoxygenase inhibitor — A Lipoxygenase inhibitor is a drug which slows down or stops the action of the lipoxygenase enzyme. More precisely, the term is almost always used to describe an inhibitor of the arachidonate 5 lipoxygenase enzyme, which transforms EFAs into… … Wikipedia
5-lipoxygenase — arachidonate 5 lipoxygenase … Medical dictionary
12-lipoxygenase — arachidonate 12 lipoxygenase … Medical dictionary
