Arachidonate 8-lipoxygenase

Arachidonate 8-lipoxygenase

In enzymology, an arachidonate 8-lipoxygenase (EC number|1.13.11.40) is an enzyme that catalyzes the chemical reaction

:arachidonate + O2 ightleftharpoons (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate

Thus, the two substrates of this enzyme are arachidonate and O2, whereas its product is (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is arachidonate:oxygen 8-oxidoreductase. Other names in common use include 8-lipoxygenase, and 8(R)-lipoxygenase. This enzyme participates in arachidonic acid metabolism.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|2FNQ.

References

*

External links

::"The CAS registry number for this enzyme class is CAS registry|100900-72-9."

Gene Ontology (GO) codes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем решить контрольную работу

Look at other dictionaries:

  • Arachidonate 5-lipoxygenase — (5 lipoxygenase, 5 LO or Alox5) is a human enzyme, member of the lipoxygenase family. It transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases.ubstrates and productsEFA substrates and… …   Wikipedia

  • Arachidonate 12-lipoxygenase — In enzymology, an arachidonate 12 lipoxygenase (EC number|1.13.11.31) is an enzyme that catalyzes the chemical reaction:arachidonate + O2 ightleftharpoons (5Z,8Z,10E,14Z) (12S) 12 hydroperoxyicosa 5,8,10,14 tetraenoateThus, the two substrates of… …   Wikipedia

  • Arachidonate 15-lipoxygenase — In enzymology, an arachidonate 15 lipoxygenase (EC number|1.13.11.33) is an enzyme that catalyzes the chemical reaction:arachidonate + O2 ightleftharpoons (5Z,8Z,11Z,13E) (15S) 15 hydroperoxyicosa 5,8,11,13 tetraenoateThus, the two substrates of… …   Wikipedia

  • arachidonate 5-lipoxygenase — arach·i·don·ate 5 lip·oxy·gen·ase (ə rak″ĭ donґāt lĭ pokґsə jən ās) [EC 1.13.11.34] an enzyme of the oxidoreductase class that catalyzes the oxidation of arachidonate at the 5 position to form 5… …   Medical dictionary

  • arachidonate 12-lipoxygenase — arach·i·don·ate 12 lip·oxy·gen·ase (ə rakґĭ don″āt lĭ pokґsə jən ās) [EC 1.13.11.31] an enzyme of the oxidoreductase class that catalyzes the oxidation of arachidonate at the 12 position to form 12… …   Medical dictionary

  • arachidonate 15-lipoxygenase — arach·i·don·ate 15 lip·oxy·ge·nase (ə rakґĭ donґāt lĭ pokґsə jən ās) [EC 1.13.11.33] an enzyme of the oxidoreductase class that catalyzes the oxidation of arachidonate at the 15 position to form 15… …   Medical dictionary

  • Lipoxygenase — Pfam box Symbol = Lipoxygenase Name = width =220 caption = Arachidonate 15 Lipoxygenase Pfam= PF00305 InterPro= IPR013819 SMART= PROSITE = PDOC00077 SCOP = 2sbl TCDB = OPM family= 87 OPM protein= 1zq4 PDB=PDB3|1y4kA:155 823 PDB3|2sblB:155 823… …   Wikipedia

  • Lipoxygenase inhibitor — A Lipoxygenase inhibitor is a drug which slows down or stops the action of the lipoxygenase enzyme. More precisely, the term is almost always used to describe an inhibitor of the arachidonate 5 lipoxygenase enzyme, which transforms EFAs into… …   Wikipedia

  • 5-lipoxygenase — arachidonate 5 lipoxygenase …   Medical dictionary

  • 12-lipoxygenase — arachidonate 12 lipoxygenase …   Medical dictionary

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”