- Leukotriene-C4 synthase
In
enzymology , a leukotriene-C4 synthase (EC number|4.4.1.20) is anenzyme that catalyzes thechemical reaction :leukotriene C4 leukotriene A4 + glutathione
Hence, this enzyme has one substrate,
leukotriene C4 , and two products,leukotriene A4 andglutathione .This enzyme belongs to the family of
lyase s, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is leukotriene-C4 glutathione-lyase (leukotriene-A4-forming). Other names in common use include leukotriene C4 synthetase, LTC4 synthase, LTC4 synthetase, leukotriene A4:glutathione S-leukotrienyltransferase, (7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-, tetraenoate:glutathione leukotriene-transferase, (epoxide-ring-opening), (7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-, and 7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming). This enzyme participates inarachidonic acid metabolism .tructural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2PNO, PDB link|2UUH, and PDB link|2UUI.
References
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*External links
::"The
CAS registry number for this enzyme class is CAS registry|90698-32-1."Gene Ontology (GO) codes
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