- Deoxyribonuclease II
deoxyribonuclease II alpha Identifiers Symbol DNASE2 Alt. symbols DNASE2A, DRN2, DNL, DNL2 Entrez 1777 HUGO 2960 OMIM 126350 RefSeq NM_001375 UniProt O00115 Other data EC number 220.127.116.11 Locus Chr. 19 p13.2 deoxyribonuclease II beta Identifiers Symbol DNASE2B Entrez 58511 HUGO 28875 OMIM 608057 RefSeq NM_021233 UniProt Q8WZ79 Other data EC number 18.104.22.168 Locus Chr. 1 p22.3
Deoxyribonuclease II, or Acid DNase, hydrolyzes deoxyribonucleotide linkages in native and denatured DNA, yielding products with 3'-phosphates. As the name implies, it is more effective at acid pH.
There are several known DNases II, including:
either deoxy- or ribo-
- DNase II alpha (usually just called DNase II)
- DNase II beta (also called DLAD, or DNase II-Like Acid DNase)
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