RNASE1

Ribonuclease, RNase A family, 1 (pancreatic), also known as RNASE1, is a human gene.cite web | title = Entrez Gene: RNASE1 ribonuclease, RNase A family, 1 (pancreatic)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6035| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.cite web | title = Entrez Gene: RNASE1 ribonuclease, RNase A family, 1 (pancreatic)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6035| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nogués MV, Vilanova M, Cuchillo CM |title=Bovine pancreatic ribonuclease A as a model of an enzyme with multiple substrate binding sites. |journal=Biochim. Biophys. Acta |volume=1253 |issue= 1 |pages= 16–24 |year= 1996 |pmid= 7492594 |doi=
*cite journal | author=Schienman JE, Holt RA, Auerbach MR, Stewart CB |title=Duplication and divergence of 2 distinct pancreatic ribonuclease genes in leaf-eating African and Asian colobine monkeys. |journal=Mol. Biol. Evol. |volume=23 |issue= 8 |pages= 1465–79 |year= 2006 |pmid= 16751256 |doi= 10.1093/molbev/msl025
*cite journal | author=Sakakibara R, Hashida K, Kitahara T, Ishiguro M |title=Characterization of a unique nonsecretory ribonuclease from urine of pregnant women. |journal=J. Biochem. |volume=111 |issue= 3 |pages= 325–30 |year= 1992 |pmid= 1587793 |doi=
*cite journal | author=Haugg M, Schein CH |title=The DNA sequences of the human and hamster secretory ribonucleases determined with the polymerase chain reaction (PCR). |journal=Nucleic Acids Res. |volume=20 |issue= 3 |pages= 612 |year= 1992 |pmid= 1741299 |doi=
*cite journal | author=Sakakibara R, Hashida K, Tominaga N, "et al." |title=A putative mouse oocyte maturation inhibitory protein from urine of pregnant women: N-terminal sequence homology with human nonsecretory ribonuclease. |journal=Chem. Pharm. Bull. |volume=39 |issue= 1 |pages= 146–9 |year= 1991 |pmid= 2049798 |doi=
*cite journal | author=Mizuta K, Awazu S, Yasuda T, Kishi K |title=Purification and characterization of three ribonucleases from human kidney: comparison with urine ribonucleases. |journal=Arch. Biochem. Biophys. |volume=281 |issue= 1 |pages= 144–51 |year= 1990 |pmid= 2383019 |doi=
*cite journal | author=Beintema JJ, Blank A, Schieven GL, "et al." |title=Differences in glycosylation pattern of human secretory ribonucleases. |journal=Biochem. J. |volume=255 |issue= 2 |pages= 501–5 |year= 1989 |pmid= 3202829 |doi=
*cite journal | author=Beintema JJ, Wietzes P, Weickmann JL, Glitz DG |title=The amino acid sequence of human pancreatic ribonuclease. |journal=Anal. Biochem. |volume=136 |issue= 1 |pages= 48–64 |year= 1984 |pmid= 6201087 |doi=
*cite journal | author=Russo N, de Nigris M, Ciardiello A, "et al." |title=Expression in mammalian cells, purification and characterization of recombinant human pancreatic ribonuclease. |journal=FEBS Lett. |volume=369 |issue= 2-3 |pages= 352 |year= 1995 |pmid= 7649283 |doi=
*cite journal | author=Seno M, Futami J, Kosaka M, "et al." |title=Nucleotide sequence encoding human pancreatic ribonuclease. |journal=Biochim. Biophys. Acta |volume=1218 |issue= 3 |pages= 466–8 |year= 1994 |pmid= 8049276 |doi=
*cite journal | author=Yasuda T, Nadano D, Takeshita H, Kishi K |title=Two distinct secretory ribonucleases from human cerebrum: purification, characterization and relationships to other ribonucleases. |journal=Biochem. J. |volume=296 ( Pt 3) |issue= |pages= 617–25 |year= 1994 |pmid= 8280059 |doi=
*cite journal | author=Kochetov AV, Lukasheva VV, Filipenko ML, "et al." |title= [Primary structure of the coding part of the gene for human pancreatic ribonuclease and its chromosomal location] |journal=Bioorg. Khim. |volume=21 |issue= 9 |pages= 691–4 |year= 1996 |pmid= 8588814 |doi=
*cite journal | author=Papageorgiou AC, Shapiro R, Acharya KR |title=Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution. |journal=EMBO J. |volume=16 |issue= 17 |pages= 5162–77 |year= 1997 |pmid= 9311977 |doi= 10.1093/emboj/16.17.5162
*cite journal | author=Klink TA, Woycechowsky KJ, Taylor KM, Raines RT |title=Contribution of disulfide bonds to the conformational stability and catalytic activity of ribonuclease A. |journal=Eur. J. Biochem. |volume=267 |issue= 2 |pages= 566–72 |year= 2000 |pmid= 10632727 |doi=
*cite journal | author=Pous J, Canals A, Terzyan SS, "et al." |title=Three-dimensional structure of a human pancreatic ribonuclease variant, a step forward in the design of cytotoxic ribonucleases. |journal=J. Mol. Biol. |volume=303 |issue= 1 |pages= 49–60 |year= 2000 |pmid= 11021969 |doi= 10.1006/jmbi.2000.4506
*cite journal | author=Pous J, Mallorquí-Fernández G, Peracaula R, "et al." |title=Three-dimensional structure of human RNase 1 delta N7 at 1.9 A resolution. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=57 |issue= Pt 4 |pages= 498–505 |year= 2001 |pmid= 11264578 |doi=
*cite journal | author=Gaur D, Swaminathan S, Batra JK |title=Interaction of human pancreatic ribonuclease with human ribonuclease inhibitor. Generation of inhibitor-resistant cytotoxic variants. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 24978–84 |year= 2001 |pmid= 11342552 |doi= 10.1074/jbc.M102440200
*cite journal | author=Futami J, Maeda T, Kitazoe M, "et al." |title=Preparation of potent cytotoxic ribonucleases by cationization: enhanced cellular uptake and decreased interaction with ribonuclease inhibitor by chemical modification of carboxyl groups. |journal=Biochemistry |volume=40 |issue= 25 |pages= 7518–24 |year= 2001 |pmid= 11412105 |doi=
*cite journal | author=Canals A, Pous J, Guasch A, "et al." |title=The structure of an engineered domain-swapped ribonuclease dimer and its implications for the evolution of proteins toward oligomerization. |journal=Structure |volume=9 |issue= 10 |pages= 967–76 |year= 2002 |pmid= 11591351 |doi=

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