PDE4A

Phosphodiesterase 4A, cAMP-specific
PDB rendering based on 1loi.
Available structures PDB 2QYK, 3I8V
Identifiers
Symbols	PDE4A; DPDE2; PDE4; PDE46
External IDs	OMIM: 600126 MGI: 99558 HomoloGene: 4520 GeneCards: PDE4A Gene
EC number	3.1.4.17
Gene Ontology Molecular function • 3',5'-cyclic-AMP phosphodiesterase activity • 3',5'-cyclic-AMP phosphodiesterase activity • protein binding • phosphoric diester hydrolase activity • hydrolase activity • metal ion binding Cellular component • membrane fraction • soluble fraction • insoluble fraction • nucleus • cytoplasm • cytosol • cytosol • plasma membrane • ruffle membrane • cell projection • perinuclear region of cytoplasm Biological process • cAMP catabolic process • signal transduction • response to drug Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5141	18577
Ensembl	ENSG00000065989	ENSMUSG00000032177
UniProt	P27815	O70285
RefSeq (mRNA)	NM_001111307.1	XM_977087
RefSeq (protein)	NP_001104777.1	XP_982181
Location (UCSC)	Chr 19: 10.53 – 10.58 Mb	Chr 9: 20.97 – 21.02 Mb
PubMed search	[1]	[2]

cAMP-specific 3',5'-cyclic phosphodiesterase 4A is an enzyme that in humans is encoded by the PDE4A gene.^[1][2]

Interactions

References

1. ^ Milatovich A, Bolger G, Michaeli T, Francke U (Jul 1994). "Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse". Somat Cell Mol Genet 20 (2): 75–86. doi:10.1007/BF02290677. PMID 8009369. 
2. ^ "Entrez Gene: PDE4A phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5141. 

Further reading

• Houslay MD, Schafer P, Zhang KY (2006). "Keynote review: phosphodiesterase-4 as a therapeutic target.". Drug Discov. Today 10 (22): 1503–19. doi:10.1016/S1359-6446(05)03622-6. PMID 16257373. 
• Zhang KY, Ibrahim PN, Gillette S, Bollag G (2006). "Phosphodiesterase-4 as a potential drug target.". Expert Opin. Ther. Targets 9 (6): 1283–305. doi:10.1517/14728222.9.6.1283. PMID 16300476. 
• Livi GP, Kmetz P, McHale MM, et al. (1990). "Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase". Mol. Cell. Biol. 10 (6): 2678–86. PMC 360627. PMID 2160582. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=360627. 
• Horton YM, Sullivan M, Houslay MD (1995). "Molecular cloning of a novel splice variant of human type IVA (PDE-IVA) cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19". Biochem. J. 308 ( Pt 2) (Pt 2): 683–91. PMC 1136980. PMID 7772058. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1136980. 
• Sullivan M, Egerton M, Shakur Y, et al. (1995). "Molecular cloning and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA, cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1)". Cell. Signal. 6 (7): 793–812. doi:10.1016/0898-6568(94)00039-5. PMID 7888306. 
• Bolger G, Michaeli T, Martins T, et al. (1993). "A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs". Mol. Cell. Biol. 13 (10): 6558–71. PMC 364715. PMID 8413254. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=364715. 
• Huston E, Pooley L, Julien P, et al. (1997). "The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram". J. Biol. Chem. 271 (49): 31334–44. doi:10.1074/jbc.271.49.31334. PMID 8940140. 
• Sullivan M, Rena G, Begg F, et al. (1998). "Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2". Biochem. J. 333 ( Pt 3) (Pt 3): 693–703. PMC 1219634. PMID 9677330. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1219634. 
• McPhee I, Yarwood SJ, Scotland G, et al. (1999). "Association with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B. Consequences for rolipram inhibition". J. Biol. Chem. 274 (17): 11796–810. doi:10.1074/jbc.274.17.11796. PMID 10206997. 
• Zhou L, Thompson WJ, Potter DE (1999). "Multiple cyclic nucleotide phosphodiesterases in human trabecular meshwork cells". Invest. Ophthalmol. Vis. Sci. 40 (8): 1745–52. PMID 10393044. 
• Secchiero P, Zella D, Curreli S, et al. (2001). "Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14620–5. doi:10.1073/pnas.011512398. PMC 18968. PMID 11114167. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=18968. 
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964. 
• Rena G, Begg F, Ross A, et al. (2001). "Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10". Mol. Pharmacol. 59 (5): 996–1011. PMID 11306681. 
• Lario PI, Bobechko B, Bateman K, et al. (2001). "Purification and characterization of the human PDE4A catalytic domain (PDE4A330-723) expressed in Sf9 cells". Arch. Biochem. Biophys. 394 (1): 54–60. doi:10.1006/abbi.2001.2513. PMID 11566027. 
• Moon E, Lee R, Near R, et al. (2002). "Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia". Clin. Cancer Res. 8 (2): 589–95. PMID 11839681. 
• Laliberté F, Liu S, Gorseth E, et al. (2002). "In vitro PKA phosphorylation-mediated human PDE4A4 activation". FEBS Lett. 512 (1–3): 205–8. doi:10.1016/S0014-5793(02)02259-7. PMID 11852080. 
• Baillie GS, Huston E, Scotland G, et al. (2002). "TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid". J. Biol. Chem. 277 (31): 28298–309. doi:10.1074/jbc.M108353200. PMID 11994273. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Pryzwansky KB, Madden VJ (2004). "Type 4A cAMP-specific phosphodiesterase is stored in granules of human neutrophils and eosinophils". Cell Tissue Res. 312 (3): 301–11. doi:10.1007/s00441-003-0728-y. PMID 12764607.