PDE4B

PDE4B
Phosphodiesterase 4B, cAMP-specific

PDB rendering based on 1f0j.
Identifiers
Symbols PDE4B; DKFZp686F2182; DPDE4; MGC126529; PDE4B5; PDEIVB
External IDs OMIM600127 MGI99557 HomoloGene1953 GeneCards: PDE4B Gene
EC number 3.1.4.17
RNA expression pattern
PBB GE PDE4B 211302 s at tn.png
PBB GE PDE4B 203708 at tn.png
PBB GE PDE4B gnf1h03574 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5142 18578
Ensembl ENSG00000184588 ENSMUSG00000028525
UniProt Q07343 n/a
RefSeq (mRNA) NM_001037339.1 NM_019840
RefSeq (protein) NP_001032416.1 NP_062814
Location (UCSC) Chr 1:
66.26 – 66.84 Mb
Chr 4:
101.76 – 102.28 Mb
PubMed search [1] [2]

cAMP-specific 3',5'-cyclic phosphodiesterase 4B is an enzyme that in humans is encoded by the PDE4B gene.[1]

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[1]


References

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