Inositol-phosphate phosphatase

In enzymology, an inositol-phosphate phosphatase (EC number|3.1.3.25) is an enzyme that catalyzes the chemical reaction

:myo-inositol phosphate + H₂O $ightleftharpoons$ myo-inositol + phosphate

Thus, the two substrates of this enzyme are myo-inositol phosphate and H₂O, whereas its two products are myo-inositol and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is myo-inositol-phosphate phosphohydrolase. Other names in common use include myo-inositol-1(or 4)-monophosphatase, inositol 1-phosphatase, L-myo-inositol-1-phosphate phosphatase, myo-inositol 1-phosphatase, inositol phosphatase, inositol monophosphate phosphatase, inositol-1(or 4)-monophosphatase, myo-inositol-1(or 4)-phosphate phosphohydrolase, myo-inositol monophosphatase, and myo-inositol-1-phosphatase. This enzyme participates in 3 metabolic pathways: streptomycin biosynthesis, inositol phosphate metabolism, and phosphatidylinositol signaling system.

tructural studies

As of late 2007, 26 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1AWB, PDB link|1DK4, PDB link|1G0H, PDB link|1G0I, PDB link|1IMA, PDB link|1IMB, PDB link|1IMC, PDB link|1IMD, PDB link|1IME, PDB link|1IMF, PDB link|1LBV, PDB link|1LBW, PDB link|1LBX, PDB link|1LBY, PDB link|1LBZ, PDB link|2BJI, PDB link|2CZH, PDB link|2CZI, PDB link|2CZK, PDB link|2DDK, PDB link|2FVZ, PDB link|2HHM, PDB link|2P3N, PDB link|2P3V, PDB link|2PCR, and PDB link|2QFL.

References

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* Cockcroft, S. (Ed.), Biology of Phosphoinositides, Biology of Phosphoinositides, Oxford, 2000, p. 320-338.
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External links

::"The CAS registry number for this enzyme class is CAS registry|37184-63-7."

Gene Ontology (GO) codes