Multiple inositol-polyphosphate phosphatase

multiple inositol-polyphosphate phosphatase
Identifiers
EC number	3.1.3.62
CAS number	116958-30-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a multiple inositol-polyphosphate phosphatase (EC 3.1.3.62) is an enzyme that catalyzes the chemical reaction

myo-inositol hexakisphosphate + H₂O $\rightleftharpoons$ myo-inositol pentakisphosphate (mixed isomers) + phosphate

Thus, the two substrates of this enzyme are myo-inositol hexakisphosphate and H₂O, whereas its two products are myo-inositol pentakisphosphate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is 1D-myo-inositol-hexakisphosphate 5-phosphohydrolase. Other names in common use include inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase, inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase, inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase, inositol tetrakisphosphate phosphomonoesterase, inositol-1,3,4,5-tetrakisphosphate 3-phosphatase, and MIPP. This enzyme participates in inositol phosphate metabolism.

References

• Cullen PJ, Irvine RF, Drobak BK, Dawson AP (1989). "Inositol 1,3,4,5-tetrakisphosphate causes release of Ca2+ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate". Biochem. J. 259 (3): 931–3. PMC 1138610. PMID 2786415. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1138610. 
• Craxton A, Caffrey JJ, Burkhart W, Safrany ST, Shears SB (Pt 1). "Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase". Biochem. J. 328: 75–81. PMC 1218889. PMID 9359836. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1218889.