- Pancreatic lipase
Protein
Name=PAGENAME
caption=Cartoon diagram of human pancreatic lipase (colored bysecondary structure : alpha helices in red,beta sheet s in yellow, andrandom coil in green) in complex withpig colipase (colored blue) and asmall molecule inhibitor (upper left). From PDB|1LPB.
Symbol=PNLIP
AltSymbols=
HGNCid=9155
Chromosome=10
Arm=q
Band=26
LocusSupplementaryData=.1
ECnumber=3.1.1.3
OMIM=246600
EntrezGene=5406
RefSeq=NM_000936
UniProt=P16233
PDB=Pancreatic lipase is an
enzyme (more specifically, alipase ) secreted from thepancreas that useshydrolysis to break apartfat molecules .Bile salts secreted from theliver and stored ingallbladder are released into theduodenum where they coat and emulsify large fat droplets into smaller droplets, thus increasing the overallsurface area of the fat, which allows the lipase to break apart the fat more effectively. The resultingmonomers are then moved by way ofperistalsis along thesmall intestine to be absorbed into thelymphatic system by a specialized vessel called alacteal . This protein belongs topancreatic lipase family .Unlike some pancreatic enzymes like
trypsin which are first secreted in the inactive form (e.g.trypsinogen ), pancreatic lipase is secreted as the active enzyme.Diagnostic importance
Pancreatic lipase is secreted into the
duodenum through the duct system of the pancreas. Normally its concentration of serum is very low. The basic pancreatic lipase used to digest the fat droplets is Streapsin, found in the intestinal lumen. Under extreme disruption of pancreatic function, such aspancreatitis or pancreatic adenocarcinoma, the pancreas may begin to autolyse and release pancreatic enzymes into serum. Thus, through measurement of serum concentration of pancreatic lipase, pancreatitis can be diagnosed.ee also
*
Orlistat
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