- miR-27
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miR-27 
Conserved secondary structure of miR-27 prescursor Identifiers Symbol miR-27 Rfam RF00644 miRBase MI0000085 miRBase family MIPF0000036 Entrez 407018 HUGO 31613 Other data RNA type miRNA Domain(s) Animalia Locus Chr. 19 [1] miR-27 is a family of microRNA precursors found in animals, including humans.[1] MicroRNAs are typically transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product.[2] The excised region or, mature product, of the miR-27 precursor is the microRNA mir-27.
Herpesvirus saimiri expresses several non-coding RNAs (HSURs) which have been found to significantly reduce the level of mir-27 in a host cell.[3] It has been proposed that miR-27 operates together with miR-23 and mir-24 in a co-operative cluster.[4]
Functions
miR-27 is one of a number of microRNAs implicated in cholesterol homeostasis and fatty acid metabolism.[5] It is also thought to be a activator of the Wnt signaling pathway, affecting the differentiation of mesenchymal stem cells.[6]
mir-27 is known to regulate components involved in numerous types of cancer, including breast[7][8] and ovarian.[9]
References
- ^ Landgraf, P; Rusu, M, Sheridan, R, Sewer, A, Iovino, N, Aravin, A, Pfeffer, S, Rice, A et al. (2007 Jun 29). "A mammalian microRNA expression atlas based on small RNA library sequencing.". Cell 129 (7): 1401–14. PMID 17604727.
- ^ Ambros, V (2001). "microRNAs: tiny regulators with great potential". Cell 107 (7): 823–826. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
- ^ Cazalla, D; Yario, T, Steitz, JA (2010 Jun 18). "Down-regulation of a host microRNA by a Herpesvirus saimiri noncoding RNA.". Science (New York, N.Y.) 328 (5985): 1563–6. PMID 20558719.
- ^ Chhabra, R; Dubey, R, Saini, N (2010 Sep 3). "Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24-2 cluster and its implication in human diseases.". Molecular cancer 9: 232. PMID 20815877.
- ^ Fernández-Hernando, C; Suárez, Y, Rayner, KJ, Moore, KJ (2011 Apr). "MicroRNAs in lipid metabolism.". Current opinion in lipidology 22 (2): 86–92. PMID 21178770.
- ^ Wang, T; Xu, Z (2010 Nov 12). "miR-27 promotes osteoblast differentiation by modulating Wnt signaling.". Biochemical and biophysical research communications 402 (2): 186–9. PMID 20708603.
- ^ Li, X; Mertens-Talcott, SU, Zhang, S, Kim, K, Ball, J, Safe, S (2010 Jun). "MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells.". Endocrinology 151 (6): 2462–73. PMID 20382698.
- ^ Guttilla, IK; White, BA (2009 Aug 28). "Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells.". The Journal of biological chemistry 284 (35): 23204–16. PMID 19574223.
- ^ Kontorovich, T; Levy, A, Korostishevsky, M, Nir, U, Friedman, E (2010 Aug 1). "Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women.". International journal of cancer. Journal international du cancer 127 (3): 589–97. PMID 19950226.
External links
miRNA precursor families 1-100 101-200 201+ Other Categories:- Genes on chromosome 19
- MicroRNA
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