Dazoxiben

Dazoxiben: Dazoxiben

Identifiers

CAS number 78218-09-4^N

PubChem 53001

ChemSpider 47885^Y

DrugBank DB03052

ChEMBL CHEMBL267473^Y

Jmol-3D images Image 1

SMILES

O=C(O)c2ccc(OCCn1ccnc1)cc2

InChI

InChI=1S/C12H12N2O3/c15-12(16)10-1-3-11(4-2-10)17-8-7-14-6-5-13-9-14/h1-6,9H,7-8H2,(H,15,16)^Y
Key: XQGZSYKGWHUSDH-UHFFFAOYSA-N^Y
InChI=1/C12H12N2O3/c15-12(16)10-1-3-11(4-2-10)17-8-7-14-6-5-13-9-14/h1-6,9H,7-8H2,(H,15,16)
Key: XQGZSYKGWHUSDH-UHFFFAOYAY

Properties

Molecular formula C12H12N2O3

Molar mass 232.2 g/mol

N (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)

Infobox references

Dazoxiben is an orally active thromboxane synthase inhibitor.^[1] It has shown a significant clinical improvement in patients with Raynaud's syndrome.^[2]

References

^ Belch, J. J.; Cormie, J.; Newman, P.; McLaren, M.; Barbenel, J.; Capell, H.; Leiberman, P.; Forbes, C. D. et al. (1983). "Dazoxiben, a thromboxane synthetase inhibitor, in the treatment of Raynaud's syndrome: A double-blind trial". British journal of clinical pharmacology 15 Suppl 1 (Suppl 1): 113S–116S. PMC 1427695. PMID 6337601. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1427695. edit

^ Belch, J. J.; Cormie, J.; Newman, P.; McLaren, M.; Barbenel, J.; Capell, H.; Leiberman, P.; Forbes, C. D. et al. (1983). "Dazoxiben, a thromboxane synthetase inhibitor, in the treatment of Raynaud's syndrome: A double-blind trial". British journal of clinical pharmacology 15 Suppl 1 (Suppl 1): 113S–116S. PMC 1427695. PMID 6337601. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1427695. edit

v · d · eAntithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)

Antiplatelet drugs

Glycoprotein IIb/IIIa inhibitors

Abciximab • Eptifibatide • Tirofiban

ADP receptor/P2Y₁₂ inhibitors

thienopyridines (Clopidogrel, Prasugrel, Ticlopidine) • nucleotide/nucleoside analogs (Cangrelor, Elinogrel, Ticagrelor)

Prostaglandin analogue (PGI2)

Beraprost • Prostacyclin • Iloprost • Treprostinil

COX inhibitors

Acetylsalicylic acid/Aspirin^# • Aloxiprin • Carbasalate calcium • Indobufen • Triflusal

Thromboxane inhibitors

thromboxane synthase inhibitors (Dipyridamole, Picotamide) • receptor antagonist (Terutroban^†)

Phosphodiesterase inhibitors

Cilostazol • Dipyridamole • Triflusal

Other

Cloricromen • Ditazole

Anticoagulants

Vitamin K antagonists
(inhibit II, VII, IX, X)

coumarins: Acenocoumarol • Coumatetralyl • Dicoumarol • Ethyl biscoumacetate • Phenprocoumon • Warfarin^#

1,3-Indandiones: Clorindione • Diphenadione • Phenindione
other: Tioclomarol

Factor Xa inhibitors
(with some II inhibition)

Heparin group/
glycosaminoglycans/
(bind antithrombin)

low-molecular-weight heparin (Bemiparin, Certoparin, Dalteparin, Enoxaparin, Nadroparin, Parnaparin, Reviparin, Tinzaparin)

oligosaccharides (Fondaparinux, Idraparinux)
heparinoid (Danaparoid, Sulodexide, Dermatan sulfate)

Direct Xa inhibitors

xabans (Apixaban, Betrixaban, Edoxaban, Otamixaban, Rivaroxaban)

Direct thrombin (II) inhibitors

bivalent: Hirudin (Bivalirudin, Lepirudin, Desirudin)
univalent: Argatroban • Dabigatran • Melagatran^‡ • Ximelagatran^‡

Other

REG1 • Defibrotide • Ramatroban • Antithrombin III • Protein C (Drotrecogin alfa)

Thrombolytic drugs/
fibrinolytics

plasminogen activators: r-tPA (Alteplase, Reteplase, Tenecteplase) • UPA (Urokinase, Saruplase) • Streptokinase^# • Anistreplase • Monteplase

other serine endopeptidases: Ancrod • Fibrinolysin
Brinase

Non-medicinal
Citrate • EDTA • Oxalate

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: MYL

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns

Categories:
Drugs

Dazoxiben

Identifiers
CAS number	78218-09-4^N
PubChem	53001
ChemSpider	47885^Y
DrugBank	DB03052
ChEMBL	CHEMBL267473^Y
Jmol-3D images	Image 1
SMILES O=C(O)c2ccc(OCCn1ccnc1)cc2
InChI InChI=1S/C12H12N2O3/c15-12(16)10-1-3-11(4-2-10)17-8-7-14-6-5-13-9-14/h1-6,9H,7-8H2,(H,15,16)^Y Key: XQGZSYKGWHUSDH-UHFFFAOYSA-N^Y InChI=1/C12H12N2O3/c15-12(16)10-1-3-11(4-2-10)17-8-7-14-6-5-13-9-14/h1-6,9H,7-8H2,(H,15,16) Key: XQGZSYKGWHUSDH-UHFFFAOYAY
Properties
Molecular formula	C12H12N2O3
Molar mass	232.2 g/mol
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references