Duteplase

Duteplase: Duteplase is a plasminogen activator.^[1]

References

^ Malcolm AD, Keltai M, Walsh MJ (October 1996). "ESPRIT: a European study of the prevention of reocclusion after initial thrombolysis with duteplase in acute myocardial infarction". Eur. Heart J. 17 (10): 1522–31. PMID 8909909. http://eurheartj.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=8909909.

v · d · eAntithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)

Antiplatelet drugs

Glycoprotein IIb/IIIa inhibitors

Abciximab • Eptifibatide • Tirofiban

ADP receptor/P2Y₁₂ inhibitors

thienopyridines (Clopidogrel, Prasugrel, Ticlopidine) • nucleotide/nucleoside analogs (Cangrelor, Elinogrel, Ticagrelor)

Prostaglandin analogue (PGI2)

Beraprost • Prostacyclin • Iloprost • Treprostinil

COX inhibitors

Acetylsalicylic acid/Aspirin^# • Aloxiprin • Carbasalate calcium • Indobufen • Triflusal

Thromboxane inhibitors

thromboxane synthase inhibitors (Dipyridamole, Picotamide) • receptor antagonist (Terutroban^†)

Phosphodiesterase inhibitors

Cilostazol • Dipyridamole • Triflusal

Other

Cloricromen • Ditazole

Anticoagulants

Vitamin K antagonists
(inhibit II, VII, IX, X)

coumarins: Acenocoumarol • Coumatetralyl • Dicoumarol • Ethyl biscoumacetate • Phenprocoumon • Warfarin^#

1,3-Indandiones: Clorindione • Diphenadione • Phenindione
other: Tioclomarol

Factor Xa inhibitors
(with some II inhibition)

Heparin group/
glycosaminoglycans/
(bind antithrombin)

low-molecular-weight heparin (Bemiparin, Certoparin, Dalteparin, Enoxaparin, Nadroparin, Parnaparin, Reviparin, Tinzaparin)

oligosaccharides (Fondaparinux, Idraparinux)
heparinoid (Danaparoid, Sulodexide, Dermatan sulfate)

Direct Xa inhibitors

xabans (Apixaban, Betrixaban, Edoxaban, Otamixaban, Rivaroxaban)

Direct thrombin (II) inhibitors

bivalent: Hirudin (Bivalirudin, Lepirudin, Desirudin)
univalent: Argatroban • Dabigatran • Melagatran^‡ • Ximelagatran^‡

Other

REG1 • Defibrotide • Ramatroban • Antithrombin III • Protein C (Drotrecogin alfa)

Thrombolytic drugs/
fibrinolytics

plasminogen activators: r-tPA (Alteplase, Reteplase, Tenecteplase) • UPA (Urokinase, Saruplase) • Streptokinase^# • Anistreplase • Monteplase

other serine endopeptidases: Ancrod • Fibrinolysin
Brinase

Non-medicinal
Citrate • EDTA • Oxalate

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: MYL

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns

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