- Dalteparin
Dalteparin is a
low molecular weight heparin . It is marketed as Fragmin by Pfizer Inc. Like other low molecular weight heparins, dalteparin is used for prophylaxis or treatment ofdeep vein thrombosis andpulmonary embolism .The CLOT study, published in 2003, showed that in patients with malignancy and acute venous thromboembolism, dalteparin was more effective than
coumadin in reducing the risk of recurrent embolic events. [cite journal | author=Lee AY, Levine MN, Baker RI, Bowden C, Kakkar AK, Prins M, Rickles FR, Julian JA, Haley S, Kovacs MJ, Gent M | title=Low-molecular-weight heparin versus a Coumadin for the prevention of recurrent venous thromboembolism in patients with cancer | journal=N Engl J Med | year=2003 | pages=146–53 | volume=349 | issue=2 | pmid=12853587 | doi=10.1056/NEJMoa025313]Dalteparin is the only low molecular weight heparin shown to be safe in critically ill people with
renal failure . Heparins are cleared by the kidneys, but studies have shown that dalteparin does not accumulate even if kidney function is reduced. [cite journal | author=Douketis J, Cook D, Meade M "et al" | title=Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin dalteparin | journal=Arch Intern Med | year=2008 | volume=168 | issue=16 | pages=1805–1812 | doi=10.1001/archinte.168.16.1805]References
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