Infant formula

Infant formula
An infant being fed from a baby bottle.

Infant formula is a manufactured food designed and marketed for feeding to babies and infants under 12 months of age, usually prepared for bottle-feeding or cup-feeding from powder (mixed with water) or liquid (with or without additional water). The U.S. Federal Food, Drug, and Cosmetic Act (FFDCA) defines infant formula as "a food which purports to be or is represented for special dietary use solely as a food for infants by reason of its simulation of human milk or its suitability as a complete or partial substitute for human milk".[1]

The composition of infant formula is designed to be roughly based on a human mother's milk at approximately one to three months postpartum, although there are significant differences in the nutrient content of these products.[2] The most commonly used infant formulas contain purified cow's milk whey and casein as a protein source, a blend of vegetable oils as a fat source, lactose as a carbohydrate source, a vitamin-mineral mix, and other ingredients depending on the manufacturer.[3] In addition, there are infant formulas using soybean as a protein source in place of cow's milk (mostly in the United States and Great Britain) and formulas using protein reduced (hydrolysed) into its component amino acids for infants who are allergic to other proteins. An upswing in breastfeeding in many countries has been accompanied by a deferment in the average age of introduction of baby foods (including cow's milk), resulting in both increased breastfeeding and increased use of infant formula between the ages of 3- and 12-months.[4][5]

A 2001 World Health Organization (WHO) report found that infant formula prepared in accordance with applicable Codex Alimentarius standards was a safe complementary food and a suitable breast milk substitute. In 2003, the WHO and UNICEF published their "Global Strategy for Infant and Young Child Feeding," which restated that "processed-food products for infants and young children should, when sold or otherwise distributed, meet applicable standards recommended by the Codex Alimentarius Commission," and also warned that "lack of breastfeeding – and especially lack of exclusive breastfeeding during the first half-year of life – are important risk factors for infant and childhood morbidity and mortality". In particular, the use of infant formula in less economically-developed countries is linked to poorer health outcomes because of the prevalence of unsanitary preparation conditions, including lack of clean water and lack of sanitizing equipment.[6] UNICEF estimates that a formula-fed child living in unhygienic conditions is between 6 and 25 times more likely to die of diarrhea and four times more likely to die of pneumonia than a breastfed child.[7] Rarely, use of powdered infant formula (PIF) has been associated with serious illness, and even death, due to infection with Enterobacter sakazakii and other microorganisms that can be introduced to PIF during its production. Although E. sakazakii can cause illness in all age groups, infants are believed to be at greatest risk of infection. Between 1958 and 2006, there have been several dozen reported cases of E. sakazakii infection worldwide. The WHO believes that such infections are under-reported.[8]

The WHO, UNICEF and other national and international health agencies, with few exceptions, now recommend exclusive breastfeeding for the first six months of life. Infant formula is considered an imperfect approximation of breast milk because:

  • The exact chemical properties of breast milk are not fully understood.[9]
  • A mother's breast milk changes in response to the feeding habits of her baby and over time, thus adjusting to the infant's individual growth and development.[10]
  • Breast milk includes the mothers' antibodies that help the babies avoid or fight off infections and give their immature immune systems the benefit of their mothers' immune system that has many years of experience with the germs common in their environments.


History of formula

Early infant foods

Throughout history, mothers who could not breastfeed their babies either employed a wet nurse[11] or, less frequently, prepared food for their babies, a process known as "dry nursing".[11][12] Baby food composition varied according to region and economic status.[12] In Europe and America during the early 19th century, the prevalence of wet nursing began to decrease, while the practice of feeding babies mixtures based on animal milk rose in popularity.[13][14]

Poster advertisement for Nestle's Milk by Théophile Alexandre Steinlen, 1895

This trend was driven by cultural changes as well as increased sanitation measures,[15] and it continued throughout the 19th and much of the 20th century, with a notable increase after Elijah Pratt invented and patented the India-rubber nipple in 1845.[11][16] As early as 1846, scientists and nutritionists noted an increase in medical problems and infant mortality was associated with dry nursing.[13][17] In an attempt to improve the quality of manufactured baby foods, in 1867, Justus von Liebig developed the world's first commercial infant formula, Liebig's Soluble Food for Babies.[18] The success of this product quickly gave rise to competitors such as Mellin's Infant Food, Ridge's Food for Infants and Nestlé's Milk.[19]

These findings are not supported by modern research. These studies, accompanied by the affordable price of evaporated milk and the availability of the home icebox initiated a tremendous rise in the use of evaporated milk formulas.[4] By the late 1930s, the use of evaporated milk formulas in the United States surpassed all commercial formulas, and by 1950 over half of all babies in the United States were reared on such formulas.[11]

Commercial formulas

In parallel with the enormous shift (in industrialized nations) away from breastfeeding to home-made formulas, nutrition scientists continued to analyze human milk and attempted to make infant formulas that more closely matched its composition.[4] Maltose and dextrins were believed nutritionally important, and in 1912, the Mead Johnson Company released a milk additive called Dextri-Maltose. This formula was made available to mothers only by physicians. In 1919, milkfats were replaced with a blend of animal and vegetable fats as part of the continued drive to closer simulate human milk. This formula was called SMA for "simulated milk adapted."[11]

In the late 1920s, Alfred Bosworth released Similac (for "similar to lactation"), and Mead Johnson released Sobee.[11] Several other formulas were released over the next few decades, but commercial formulas did not begin to seriously compete with evaporated milk formulas until the 1950s. The reformulation and concentration of Similac in 1951, and the introduction (by Mead Johnson) of Enfamil in 1959 were accompanied by marketing campaigns that provided inexpensive formula to hospitals and pediatricians.[11] By the early 1960s, commercial formulas were more commonly used than evaporated milk formulas in the United States, which all but vanished in the 1970s. By the early 1970s, over 75% of American babies were fed on formulas, almost entirely commercially produced.[4]

When birth rates in industrial nations tapered off during the 1960s, infant formula companies heightened marketing campaigns in non-industrialized countries. Unfortunately, poor sanitation led to steeply increased mortality rates among infants fed formula prepared with contaminated (drinking) water.[20] Organized protests, the most famous of which was the Nestlé boycott of 1977, called for an end to unethical marketing. This boycott is ongoing, as the current coordinators maintain that Nestlé engages in marketing practices which violate the International Code of Marketing of Breast-milk Substitutes.

Generic brand formulas

In additional to commercially marketed brands, generic brands (or store brands) of infant formula were introduced in the United States in 1997, first by PBM Products. These private label formulas are sold by many leading food and drug retailers such as Wal-Mart, Target, Kroger, Loblaws, and Walgreens. All infant formula brands in the United States are required to adhere to the Food and Drug Administration (FDA) guidelines. As reported by the Mayo Clinic: “as with most consumer products, brand-name infant formulas cost more than generic brands. But that doesn't mean that brand-name [Similac, Nestle, Enfamil] formulas are better. Although manufacturers may vary somewhat in their formula recipes, the FDA requires that all formulas contain the same nutrient density.”[21]

Similarly, in Canada all infant formulas regardless of brand are required to meet standards set by Health Canada.[22]

Follow-on and toddler formulas

In the 1980s and 1990s, some companies introduced formula versions for older children, generally marketed for use from age 12 months up to about 2 or 3 years, under such terms as "follow-on formula" and "toddler formula".[23] This was done partly because the market for infant formula (generally up to age 6 or 12 months, when infants are typically breastfeed) was considered largely saturated, and in conjunction with regulations on infant formula advertising. Critics have argued that follow-on and toddler formulas were introduced partly to circumvent these regulations and have resulted in confusing advertising.[24]

An early example of follow-on formula was introduced by Wyeth in the Philippines in 1987, following the introduction in this country of regulations on infant formula advertising, but which did not address follow-on formulas (products that did not exist at the time of their drafting).[25] Similarly, while infant formula advertising is illegal in the United Kingdom, follow-on formula advertising is legal, and the similar packaging and market results in follow-on advertisements frequently being interpreted as advertisements for formula.[24] (See also industry and marketing, below.)

These products have also recently fallen under criticism for contributing to the childhood obesity epidemic in some developed countries due to their marketing and flavoring practices.[26]

Usage since 1970s

Since the early 1970s, industrial countries have witnessed a resurgence in breastfeeding among newborns and infants to 6 months of age.[5] This upswing in breastfeeding has been accompanied by a deferment in the average age of introduction of other foods (such as cow's milk), resulting in increased use of both breastfeeding and infant formula between the ages of 3–12 months.[4][5]

The global infant formula market has been estimated at $7.9 billion[27], with North America and Western Europe accounting for 33% of the market and considered largely saturated, and Asia representing 53% of the market.[28] South East Asia is a particularly large fraction of the world market relative to its population.[28] Infant formula is the largest segment of the baby food market,[28][29] with the fraction given as between 40%[28] and 70%.[29][27]

Leading health organizations (e.g. WHO, U.S. Center for Disease Control and Department of Health and Human Services) are attempting to reduce the use of infant formula and increase the prevalence of breastfeeding from birth through 12 to 24 months of age through public health awareness campaigns.[30][31][32][33] The specific goals and approaches of these breastfeeding promotion programs, and the policy environment surrounding their implementation, vary by country. As a policy basic framework, the International Code of Marketing of Breast-milk Substitutes, adopted by the WHO's World Health Assembly in 1981, requires infant formula companies to preface their product information with statements that breastfeeding is the best way of feeding babies and that a substitute should only be used after consultation with health professionals.[34] The Baby Friendly Hospital Initiative also restricts use by hospitals of free formula or other infant care aids provided by formula companies. (See also Policy section below.)

Preparation and content


Infant formulas come in powder, liquid concentrate, and ready-to-feed forms. They are designed to be prepared by the parent or caregiver in small batches and fed to the infant, usually with either a cup, as recommended by the WHO[6], or a baby bottle.

Infant formulas also come in a variety of types:

  • Cow's milk formula is the "typical" most commonly used type (e.g.: Similac, Enfamil).
  • Soy protein based formulas are frequently used for infants allergic to cow's milk (e.g.: Isomil, ProSobee).
  • Partially hydrolyzed formulas (e.g.: Good Start and Gentlease brands) are marketed as having improved digestibility.[citation needed]
  • Extensively hydrolyzed formulas (e.g.: Alimentum, Nutramigen, and Pregestimil) are considered "hypoallergenic". One study reported that 90% of children with cow's milk allergies will tolerate them.[35]
  • Amino acid based formulas (e.g.: Neocate, EleCare, and Nutramigen AA) are more expensive, but are reported least likely to cause allergic reactions.[36]

Hypoallergenic formulas, such as those synthesized from raw amino acids, and sometimes referred to as elemental infant formula, are considered to reduce the likelihood of certain medical complications in babies with specific health problems, such as severe allergies to cow's milk and soy. Being made of purely synthetic monomeric amino acids, they are often considered quite foul-tasting, and it is not uncommon for infants to reject elemental formulas after having been established on a sweeter-tasting regular formula.[citation needed]

Manufacturers and health officials advise it is very important to measure powders or concentrates accurately to achieve the intended final product concentration; otherwise, the child will be malnourished. It is advisable that all equipment that comes into contact with the infant formula be cleaned and sterilized before each use. Proper refrigeration is essential for any infant formula which is prepared in advance.

In developing countries, formula is frequently prepared improperly, resulting in high infant mortality due to malnutrition and diseases such as diarrhea and pneumonia. This is due to lack of clean water, lack of sterile conditions, lack of refrigeration, illiteracy (so written instructions cannot be followed), poverty (diluting formula so that it lasts longer), and lack of education of mothers by formula distributors. These problems and resulting disease and death are a key factor in opposition to the marketing and distribution of infant formula in developing countries by numerous public health agencies and NGOs (discussed in more detail at Nestlé boycott and International Code of Marketing of Breast-milk Substitutes).

Nutritional content

Infant formula is nutritionally inferior to breast milk[6] but superior to other substitutes, such as milk from cows. Besides breast milk, infant formula is the only other milk product which the medical community considers nutritionally acceptable for infants under the age of one year. Supplementing with solid food in addition to breast milk or formula begins during weaning, and most babies begin supplementing about the time their first teeth appear, usually around the age of six months.

Although cow's milk is the basis of almost all infant formula, plain cow's milk is unsuited for infants because of its high casein content and low whey content, which may put a strain on an infant's immature kidneys, and untreated cow's milk is not recommended before the age of 12 months. The infant intestine is not properly equipped to digest non-human milk, and this may often result in diarrhea, intestinal bleeding and malnutrition.[37] To reduce the negative effect on the infant's digestive system, cow's milk used for formula undergoes processing to be made into infant formula. This includes steps to make protein more easily digestible and alter the whey-to-casein protein balance to one closer to human milk, the addition of several essential ingredients (often called "fortification", see below), the partial or total replacement of dairy fat with fats of vegetable or marine origin, etc.

The nutrient content of infant formula for sale in the United States is regulated by the Food and Drug Administration (FDA) based on recommendations by the American Academy of Pediatrics Committee on Nutrition. The following must be included in all formulas produced in the U.S.:[38]

  • Protein
  • Fat
  • Linoleic acid
  • Vitamins: A, C, D, E, K, thiamin (B1), riboflavin (B2), B6, B12
  • Niacin
  • Folic acid
  • Pantothenic acid
  • Calcium
  • Minerals: magnesium, iron, zinc, manganese, copper
  • Phosphorus
  • Iodine
  • Sodium chloride
  • Potassium chloride
  • Carbohydrates
    • Carbohydrates are an important source of energy for growing infants, as they account for 35 to 42% of their daily energy intake. In most cow's milk-based formulas, lactose is the main source of carbohydrates present, but lactose is not present in cow's milk-based lactose-free formulas nor specialized non-milk protein formulas or hydrolyzed protein formulas for infants with milk protein sensitivity. Lactose is also not present in soy-based formulas. Therefore, those formulas without lactose will use other sources of carbohydrates, such as sucrose and glucose, dextrins, and natural and modified starches. Lactose is not only a good source of energy, it also aids in the absorption of the minerals magnesium, calcium, zinc and iron.[39]
  • Nucleotides
    • Nucleotides are compounds found naturally in human breast milk. They are involved in critical metabolic processes, such as energy metabolism and enzymatic reactions. Also, as the building blocks of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), they are essential for normal body functions. Compared to human breast milk, cow's milk has lower levels of the nucleotides uridine, inosine, and cytidine. Therefore, several companies that produce infant formula have added nucleotides to their infant formulas.[39]

Other commonly used ingredients:

  • Emulsifiers and stabilizers: Ingredients added to prevent the separation of the oil from the water (and its soluble components) in the infant formula. Some commonly used emulsifiers include monoglycerides, diglycerides, and gums.[38]
  • Diluents: Skim milk is commonly used as the primary diluent in milk-based liquid formula to provide the bulk of the volume. In contrast, purified water is the most commonly used diluent in milk-free formulations.[38]

In addition, formulas not made with cow's milk include biotin, choline, and inositol.

Uses, risks and controversies

The use and marketing of infant formula has come under scrutiny. Breastfeeding, including exclusive breastfeeding for the first 6 months of life, is widely advocated as "ideal" for babies and infants, both by health authorities[6][33] — and accordingly in ethical advertising of infant formula manufacturers[40].

Despite the recommendation that babies be exclusively breastfed for the first 6 months, less than 40% of infants less than this age are exclusively breastfed worldwide.[41] The overwhelming majority of American babies are not exclusively breastfed for this period – in 2005 under 12% of babies were breastfed exclusively for the first 6 months,[33] with over 60% of babies of 2 months of age being fed formula,[42] and approximately one in four breastfed infants having infant formula feeding within two days of birth.[43]

Some studies have shown that use of formula can vary according to the parents' socio-economic status, ethnicity or other characteristics. For example, according to a research conducted in Vancouver, Canada, 82.9% of mothers breastfeed their babies at birth, but the number differed between Caucasians (91.6%) and non-Caucasians (56.8%), with the difference essentially attributed to marital status, education and family income.[44] In the United States, mothers of lower socio-economic status have been found less likely to breastfeed, although this may be partly related to adverse effects of government nutrition supplementation programs that provide subsidies for infant formula.[45]

Use of infant formula

There are few medical reasons to use infant formula; breastfeeding is suitable for most mothers and babies[6]. Infant formula is the most common alternative to breastfeeding. Other options include bottle-feeding the mother's expressed breast milk, breast milk from a healthy wet nurse, and bottle-feeding breast milk from another woman collected through a human-milk bank.[6]

Some mothers are unable to breastfeed, and others choose not to breastfeed, or choose to combine breastfeeding with use of infant formula. Reasons for using formula may include:

  • The mother's health: The mother is infected with HIV or has active tuberculosis.[46] She is malnourished, extremely ill or has had certain kinds of breast surgery. She is taking any kind of drug that could harm the baby,[46] or drinks unsafe levels of alcohol.
    • One of the main global risks posed by breastmilk specifically is the transmission of HIV and other infectious diseases. Breastfeeding by an HIV-infected mother poses a 5–20% chance of transmitting HIV to the baby.[47][48][49] Cytomegalovirus infection poses potentially dangerous consequences for pre-term babies.[48][50] Other risks include mother's infection with HTLV-1 or HTLV-2 (viruses that could cause T-cell leukemia in the baby)[48][49], herpes simplex when lesions are present on the breasts[49], and chickenpox in the newborn when the disease manifested in the mother within a few days of birth[49]. In some cases these risks can be mitigated by using heat-treated milk and nursing for a briefer time (e.g. 6 months, rather than 18–24 months), and can be avoided by using an uninfected woman's milk, as via a wet-nurse or milk bank, or by using infant formula and/or treated milk.[51]
    • In balancing the risks, such as cases where the mother is infected with HIV, a decision to use infant formula versus exclusive breastfeeding may be made based on alternatives that satisfy the “AFASS” (Acceptable, Feasible, Affordable, Sustainable and Safe) principles.[51][52]
  • The baby is unable to breastfeed: The child has a birth defect or inborn error of metabolism such as galactosemia that makes breastfeeding difficult or impossible.
  • The baby is considered at risk for malnutrition: In certain circumstances infants may be at risk for malnutrition, such as due to iron deficiency, vitamin deficiencies (e.g. vitamin D which may be less present in breastmilk than needed at high latitudes where there is less sun exposure), or inadequate nutrition during transition to solid foods.[53] However these risks can often be mitigated with improved diet and education of mothers and caregivers, including availability of macro and micronutrients. For example in Canada, marketed infant formulas are fortified with vitamin D, but Health Canada also recommends breastfed infants receive extra vitamin D in the form of a supplement.[54]
  • Personal preferences and beliefs: The mother may dislike breast-feeding or think it inconvenient.[55] She may feel that breasts are too sexual for a baby, or that bottle-feeding will increase the father's role in parenting his child.
  • Absence of the mother: The child is adopted, orphaned, abandoned, or in the sole custody of a man. The mother is separated from her child by being in prison or a mental hospital. The mother has left the child in the care of another person for an extended period of time, such as while traveling or working abroad.
  • Food allergies: The mother eats foods that may provoke an allergic reaction in the infant.[citation needed]
  • Financial pressures: Maternity leave is unpaid, insufficient, or lacking. The mother's employment interferes with breastfeeding.
  • Societal structure: Breastfeeding may be forbidden at the mother's job, school, place of worship or in other public places, or the mother may feel that breastfeeding in these places or around other people is immodest, unsanitary, or inappropriate.
  • Social pressures: Family members, such as mother's husband or boyfriend, or friends or other members of society may encourage the use of infant formula. For example, they may believe that breastfeeding will decrease the mother's energy, health, or attractiveness.
  • Lack of training: The mother is not trained sufficiently to breastfeed without pain and to produce enough milk.
  • Lactation insufficiency: The mother is unable to produce sufficient milk. In studies that do not account for lactation failure with obvious causes (such as use of formula and/or breast pumps), this affects around 2 to 5% of women.[56] Alternatively, despite a healthy supply, the woman or her family may incorrectly believe that her breast milk is of low quality or in low supply. These women may choose infant formula either exclusively or as a supplement to breastfeeding.
  • Fear of exposure to environmental contaminants: Certain environmental pollutants, such as polychlorinated biphenyls, can bioaccumulate in the food chain and may be found in humans including mothers' breastmilk.[57]
    • However studies have shown that the greatest risk period for adverse effects from environmental exposures is prenatally.[57] Other studies have further found that the levels of most persistent organohalogen compounds in human milk decreased significantly over the past three decades and equally did their exposure through breastfeeding[58].
    • Research on risks from chemical pollution is generally inconclusive in terms of outweighing the benefits of breastfeeding.[59][60]. Studies supported by the WHO and others have found that neurological benefits of breast milk remain, regardless of dioxin exposure.[61][60] It has also been reported that "adverse effects on learning and behavior are strongly associated with fetal exposure to persistent pollutants, not with breast milk exposure".[62]
    • In developing countries, environmental contaminants associated with increased health risks from use of infant formula, particularly diarrhea due to unclean water and lack of sterile conditions – both prerequisites to the safe use of formula – often outweigh any risks from breastfeeding.
  • Lack of other sources of breastmilk:
    • Lack of wet nurses: Wet nursing is illegal and stigmatized in some countries, and may not be available.[63] It may also be socially unsupported, expensive, or health screening of wet nurses may not be available. The mother, her doctor,[64] or family may not know that wet nursing is possible, or may believe that nursing by a relative or paid wet-nurse is unhygienic.
    • Lack of milk banks: Human-milk banks may not be available, as few exist, and many countries cannot provide the necessary screening for diseases and refrigeration.

Health risks

Use of infant formula has been cited for numerous increased health risks. Studies have found infants in developed countries who consume formula are at increased risk for acute otitis media, gastroenteritis, severe lower respiratory tract infections, atopic dermatitis, asthma, obesity, type 1 and 2 diabetes, sudden infant death syndrome (SIDS), eczema, necrotizing enterocolitis and autism when compared to infants who are breastfed.[65][66][67][68] Some studies have found an association between infant formula and lower cognitive development, including iron supplementation in baby formula being linked to lowered I.Q. and other neurodevelopmental delays[69][70]; however other studies have found no correlation.[65]

In addition, mothers who forego breastfeeding in favour of formula feeding are reported more likely to develop certain types of cancer.[71]

Melamine contamination

Health officials around the world have been on alert for melamine contamination in infant formula since the 2008 discovery of a massive case of melamine poisoning in China, where milk was deliberately adulterated with the chemical, leading to illnesses in more than 300,000 infants, including cases of acute kidney failure, and blamed for the deaths of at least six babies. Large quantities of melamine were added to watered-down milk to give it the appearance of having adequate protein levels.[72]

In November 2008, traces of melamine were reported to have been found by the U.S. Food and Drug Administration in infant formula sold in the United States made by the three main American firms[73][74]Abbott Laboratories, Nestle and Mead Johnson — responsible for 90-99% of the infant formula market in that country.[73][45] The levels were much less than those reported in China, where levels of melamine contamination had reached as much as 2,500 parts per million, about 10,000 times higher than the recorded US levels. The material safety data sheet for melamine (CAS registry number 108-78-1; C3-H6-N6) recorded the acute oral toxicity (median lethal dose) at 3161 mg/kg (3161 ppm) for a rat.

Health Canada conducted a separate test and also detected traces of melamine in infant formula available in Canada. The melamine levels were well below Health Canada's safety limits[75], although concerns remain about the safety of manufactured food for infants and monitoring of potentially dangerous substances.[72]

Other health controversies

  • In 1985, Syntex was ordered to pay $27 million in compensation for the deaths of two American infants who suffered brain damage after drinking the company's baby formula, called Neo-mull-soy.[76] Formulas produced by Syntex had previously been subject to a major recall as they were found to have insufficient chloride to support normal infant growth and development.[77]
  • In 2010, Abbott Laboratories issued a voluntary recall of about five million Similac brand powder infant formulas that were sold in the United States, Guam, Puerto Rico and some Caribbean countries. The recall was issued after the presence of a 'small common beetle' was found in the product.[78][79]
  • In Canada, New Zealand and elsewhere, public concerns have been raised over the continued sale and marketing of soy-based formulae potentially containing high levels of phytoestrogens[80][81], linked to abnormal child development[82] including damage to babies' thyroid glands.

Policy, industry and marketing

The policy, regulatory and industry environments surrounding the infant formula market vary tremendously between countries.


The International Code of Marketing of Breast-milk Substitutes is an international health policy framework adopted by the World Health Assembly of the WHO in 1981 regarding infant formula marketing, including strict restrictions on advertising.[34] Its implementation depends on the laws of different countries and the behavior of infant formula manufacturers – the code has no power itself. Legislation and corporate behavior vary significantly between countries: at least 65 countries have enacted national legislation implementing all or many of the provisions of the Code[83]; whereas elsewhere neither the Code nor its principles are followed by governments or formula manufacturers.

Practices that are banned in the Code include most advertising, claiming health benefits for formula, and giving free samples to women able to breastfeed – this latter practice is particularly criticized because it can interfere with lactation, creating dependence on formula. In many countries free samples of infant formula have been provided to hospitals for decades; infant formula is often the only product routinely provided free of charge to hospitals.[84] The Baby Friendly Hospital Initiative aims to reduce and eliminate this controversial practice.

By country


Infant formula is one of the top three consumer commodities in the Philippines, and among the most imported products.[85] Annual sales amount to some US$469 million annually. US$88 million is spent on advertising the product.[86]

Infant formula marketing has been regulated since the 1987 Executive Order 51 or "Milk Code"[25], which regulated, but did not ban, practices such as advertising and providing free samples. Shortly after it was enacted, Wyeth introduced "follow-on formula", which was not in the purview of the Milk Code which predated its market entry.

In 2006, the Department of Health banned the advertising of infant formula and the practice of providing free samples, regardless of intended age group (in the Revised Implementing Rules and Regulations of Executive Order 51, or RIRR).[87] The new regulation was challenged by the infant formula industry in the Supreme Court. Initially the challenge was dismissed, but this decision was reversed following industry pressure and a controversial letter by American business leader Thomas Donahue,[88] then President and CEO of the US Chamber of Commerce, resulting in the regulation being suspended and advertising continuing.[87][25][85][89]

United Kingdom

In the United Kingdom, infant formula advertising has been illegal since 1995,[90] but advertising for "follow-on formula" is legal, which has been cited as a loophole allowing advertising of similarly-packaged formula.[24]

United States

In the United States, infant formula is both heavily marketed – the country has not adopted the Code, nor is it being systematically implemented by manufacturers for domestic marketing[91] – and even heavily subsidized by the government: at least one third of the American market is supported by the government,[27] with over half of infant formula sold in the country provided through the Special Supplemental Nutrition Program for Women, Infants and Children (known as WIC).[45].

According to surveys, over 70% of large U.S. hospitals dispense infant formula to all infants, a practice opposed by the American Academy of Pediatrics and in violation of the Code.[92] The Gerber Products Company began marketing its brand of infant formula directly to the public in October 1989, while the Carnation Company began marketing Good Start infant formula directly to the public in January 1991.[92]

Infant formula costs are a significant fraction of the WIC program costs: 21% post-rebate and 46% pre-rebate.[45] Formula manufacturers are granted a WIC monopoly in individual states.[45] Meanwhile breastfeeding rates are substantially lower for WIC recipients;[71] this is partly attributed to formula being free of charge to mothers in the WIC program, who are of lower socio-economic status.[45] Violations of federal policy have also been found in terms of infant formula company advertising using the WIC trademark, to reach both WIC and non-WIC participants.[71] In recent years WIC has been expanding its breastfeeding promotion strategies, including providing subsidies for clients who use milk banks.[93]

Infant Formula Processing

History of Infant Formula Development

Dates Events
1867 A formula containing wheat flour, cow's milk, malt flour, and potassium bicarbonate was developed.[94]
1915 A powder form of infant formula was introduced, containing cow's milk, lactose, oleo oils, and vegetable oils.[94]
1929 Soy formula was introduced.[94]
1935 Protein was added because it was believed cow's milk protein content was lower than human milk protein content; protein at 3.3–4.0 g/100 kcal was added.[94]
1959 Iron fortification was introduced because a large amount of iron (~80%) is used to expand the red blood cell mass in a growing infant. Infants with birth weights between 1500 and 2500g require 2 mg/kg of iron per day. Infants with weights of less than 1500g require 4 mg/kg per day.[94][95]
1962 The whey:casein ratio was made similar to human milk because producers were aware that human milk contains a higher ratio of whey protein, and cow's milk contains a higher ratio of casein.[94]
1984 Taurine fortification was introduced because newborn infants lack the enzymes needed to convert and form taurine.[94][96]
Late 1990 Nucleotide fortification was introduced into infant formula because nucleotides can act as growth factors and may enhance the infant immune system.[94]
Early 2000 Polyunsaturated fatty acid fortification was introduced. Polyunsaturated fatty acids, such as docosahexaenoic acid (DHA) and arachidonic acid (ARA), were added because those fatty acids play an important role in infant brain development.[94]

Current general procedure for infant formula processing

The manufacturing process may differ for different types of formula made; therefore the following is the general procedure for liquid-milk based formulas:[38]

Mixing ingredients

Primary ingredients are blended in large stainless steel tanks and skim milk is added and adjusted to 60°C. Then, fats, oils and emulsifiers are added. Additional heating and mixing may be required to get proper consistency. Next, minerals, vitamins, and stabilizing gums are added at various points, depending on their sensitivity to heat. The batch is temporarily stored and then transported by pipelines to pasteurization equipment when mixing is complete.[38]


This is a process that protects against spoilage by eliminating bacteria, yeasts and molds. It involves quickly heating and then cooling of the product under controlled conditions which micro-organisms cannot survive. The batch is held at around 85-94°C for approximately 30 seconds which is necessary to adequately reduce micro-organisms and prepare the formula for filling.[38]


This is a process which increases emulsion uniformity and stability by reducing size of fat and oil particles in the formula. It is done with a variety of mixing equipment that applies shear to the product and this mixing breaks fat and oil particles into very small droplets.[38]


Standardization is used to ensure that the key parameters like pH, fat concentration and vitamins and mineral content are correct. If insufficient levels of these are found, the batch is reworked to achieve appropriate levels. After this step, the batch is ready to be packaged.[38]


Packaging depends on manufacturer and type of equipment used, but in general, liquid formula is filled into metal cans with lids crimped into place.[38]

Heat treatment or sterilization

Finally, infant formulas are heat treated to maintain the bacteriologic quality of the product. This can be done traditionally by either retort sterilization or high-temperature short-time (HTST) treatment. Recently, ultrahigh-temperature treated formula has become more commonly used. If powdered formula is made, then spray drying would be required in addition.[97] Retort sterilization is a traditional retort sterilization method that uses 10-15mins treatment at 118°C.[97] Ultrahigh-temperature (UHT) is a method that uses a brief (2–3 seconds) treatment at 142°C. Because of the short time used, there is little protein denaturation, but the process still ensures sterility of the final product.[97]

Recent and future potential new ingredients


Recently, probiotics have become a new ingredient in many of our foods, and studies have been completed regarding the use of probiotics in infant formula[98] Several randomized, controlled trials completed recently have shown limited and short term clinical benefits for the use of probiotics in infants’ diet[98] The safety of probiotics in general and in infants, especially preterm infants, has been investigated in a limited number of controlled trials. The findings thus far suggest probiotics are generally safe.[98] Therefore, the study suggested more scientific research is necessary before a conclusion can be made about probiotic supplementation in infant formula, since the research is still quite preliminary.[98]


Prebiotics are undigestible carbohydrates that promote the growth of probiotic bacteria in the gut. Human milk contains a variety of oligosaccharides believed to be an important factor in the pattern of microflora colonization of breastfed infants. Because of variety, variability, complexity and polymorphism of the oligosaccharide composition and structure, it is currently not feasible to reproduce the oligosaccharide components of human milk in a strictly structural fashion.[99]

The European Society of Pediatric Gastroenterology, Hepatology, and Nutrition Committee on Nutrition found evidence to support short term effects of ingesting prebiotics on stool microflora of infants with increased in the number of bifidobacteria. Babies can be at risk of dehydration with the induction of softer stools, if they have the kidney immaturity and/or a poor ability to concentrate urine.[99] A reduction of pathogens has been associated with the consumption of prebiotics.[99] However, there was no evidence to support major clinical or long-term benefits.[98] Therefore, there is little evidence of beneficial effects of prebiotics in dietary products.[98]

Lysozyme and lactoferrin

Lysozyme is an enzyme that is responsible for protecting the body by damaging bacterial cell walls. Lactoferrin is a globular, multifunctional protein that has antimicrobial activity. Compared to human milk, cow’s milk has a signifactly lower levels of lysozyme and lactoferrin; therefore, the industry has an increasing interest in adding them into infant formulas.[94]

See also


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