- p14arf
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This article is about a tumor supressor gene. For ARF small GTP-binding protein, see ADP ribosylation factor.
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) Identifiers Symbol CDKN2A Alt. symbols CDKN2, MLM Entrez 1029 HUGO 1787 OMIM 600160 RefSeq NM_000077 UniProt P42771 Other data Locus Chr. 9 p21 p14ARF is an alternate reading frame (ARF) product of the CDKN2A locus. Both p16INK4a and p14ARF are involved in cell cycle regulation. p14ARF inhibits mdm2, thus promoting p53, which promotes p21 activation, which then binds and inactivates certain cyclin-CDK complexes, which would otherwise promote transcription of genes that would carry the cell through the G1/S checkpoint of the cell cycle. Loss of p14ARF by a homozygous mutation in the CDKN2A (INK4A) gene will lead to elevated levels in mdm2 and, therefore, loss of p53 function and cell cycle control.
The equivalent in mice is p19ARF.
See also
External links
Neoplasm: Tumor suppressor genes/proteins and Oncogenes/Proto-oncogenes Ligand Receptor TSP: CDH1TSP: PTCH1TSP: TGF beta receptor 2Intracellular signaling P+Ps ONCO: Beta-catenin · TSP: APCHippo signaling pathwayOther/unknownNucleus TSP: VHL · ONCO: CBL - MDM2Mitochondria Other/ungrouped M: NEO
tsoc, mrkr
tumr, epon, para
drug (L1i/1e/V03)
Cell cycle proteins Cyclin CDK CDK inhibitor P53 p63 p73 family Phases and
checkpointsOther cellular phasesCategories:- Genes on chromosome 9
- Genes
- Genetics stubs
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