- Fastigial nucleus
Brain: Fastigial nucleus Sagittal section through right cerebellar hemisphere. The right olive has also been cut sagitally. (Fastigial nucleus visible but not labeled.) Latin nucleus fastigii Gray's subject #187 796 Part of cerebellum NeuroNames hier-687 NeuroLex ID birnlex_1146
The fastigial nucleus or nucleus fastigii refers specifically to the concentration of gray matter nearest to the middle line at the anterior end of the superior vermis, and immediately over the roof of the fourth ventricle, from which it is separated by a thin layer of white matter. It is smaller than the nucleus dentatus, but somewhat larger than the nucleus emboliformis and nucleus globosus, the other two independent centers of gray matter in the cerebellum.
The fastigial nucleus is the smallest in size, with the dentate being the largest and the interposed being intermediate in size.
Relations and function
The fastigial nucleus receives its afferent input from the vermis. Most of its efferent connections travel via the inferior cerebellar peduncle to the vestibular nuclei, which is located at the junction of the pons and the medulla oblongata.
The fastigial nucleus deals with antigravity muscle groups and other synergies involved with standing and walking.
The fastigial nucleus contains excitatory axons which project beyond the cerebellum, unlike the Purkinje cells that convey the purely-inhibitory output of the cerebellar cortex. The likely neurotransmitters of the excitatory fastigial nucleus axons are glutamate and aspartate.
The Purkinje cells of the cerbellar cortex project into the deep cerebellar nuclei and inhibit the excitatory output system.
- ^ John K. Harting, Ph.D. (1997). "The Global Cerebellum '97". University of Wisconsin Medical School. http://www.neuroanatomy.wisc.edu/cere/text/P5/S/C50.htm. Retrieved 2007-06-28.
- ^ James D. Geyer, Janice M. Keating, Daniel C. Potts (1998). Neurology for the Boards. Philadelphia: Lippincott-Raven. p. 9.
- Neuroanatomy at UW cere/text/P5/fastig.htm
- NIF Search - Fastigial Nucleus via the Neuroscience Information Framework
Human brain, rhombencephalon, metencephalon: cerebellum (TA 14.1.07, GA 9.788) Surface anatomyLobesMedial/lateral Grey matter White matterInternalPeduncles Brain and spinal cord: neural tracts and fasciculi Sensory/
ascending3°: → Posterior limb of internal capsule → Postcentral gyrusFast/lateralSlow/medial
descendingPyramidalMidbrain tectum → Tectospinal tract → muscles of neck
direct: 1° (Motor cortex → Striatum) → 2° (GPi) → 3° (Lenticular fasciculus/Ansa lenticularis → Thalamic fasciculus → VL of Thalamus) → 4° (Thalamocortical radiations → Supplementary motor area) → 5° (Motor cortex)
indirect: 1° (Motor cortex → Striatum) → 2° (GPe) → 3° (Subthalamic fasciculus → Subthalamic nucleus) → 4° (Subthalamic fasciculus → GPi) → 5° (Lenticular fasciculus/Ansa lenticularis → Thalamic fasciculus → VL of Thalamus) → 6° (Thalamocortical radiations → Supplementary motor area) → 7° (Motor cortex)nigrostriatal pathway: Pars compacta → Striatum
CerebellarAfferentEfferentFlocculonodular lobe/vestibulocerebellum → Vestibulocerebellar tract → Vestibular nucleusBidirectional:
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