- Inferior olivary nucleus
Name = PAGENAME
GraySubject = 187
GrayPage = 781
Caption = Microcircuitry of the cerebellum.
Excitatory synapsesare denoted by (+) and inhibitory synapsesby (-).
Deep cerebellar nuclei.
IO: Inferior olive.
Caption2 = Transverse section of
medulla oblongatabelow the middle of the olive. (Inferior olivary nucleus labeled at center right.)
BrainInfoType = hier
BrainInfoNumber = 696
MeshName = Olivary+Nucleus
MeshNumber = A08.186.211.132.810.406.574
The inferior olivary nucleus is the largest nucleus situated in the
olivary body, part of the medulla oblongata.
It is closely associated with the
cerebellum, but its specific function is not well known.cite web |url=http://www.neuroanatomy.wisc.edu/virtualbrain/BrainStem/06Olive.html |title=Medical Neurosciences |format= |work= |accessdate=]
There is some evidence that it is stimulated by
ghrelin.cite journal |author=Zhang W, Lin TR, Hu Y, Fan Y, Zhao L, Mulholland MW |title=Activation of c-fos expression in the rat inferior olivary nucleus by ghrelin |journal=Neurosci. Lett. |volume=353 |issue=3 |pages=157–60 |year=2003 |pmid=14665405 |doi= |url=http://linkinghub.elsevier.com/retrieve/pii/S0304394003011248]
It consists of a gray folded lamina arranged in the form of an incomplete capsule, opening medially by an aperture called the
Emerging from the hilum are numerous fibers that collectively constitute the peduncle of the olive. The axons, also known as
olivocerebellar fibers, leave the olivary nucleus, exit through the hilum, and decussate with those from the opposite olive in the raphé.
internal arcuate fibers, they pass partly through and partly around the opposite olive and enter the inferior peduncleto be distributed to the cerebellar hemisphere of the opposite side from which they arise.
The fibers are smaller than the internal arcuate fibers connected with the
Fibers passing in the opposite direction from the
cerebellumto the olivary nucleus are often described, but their existence is doubtful.
Much uncertainty exists also with regard to the connections of the olive and the
Important connections between the cerebrum and the olive of the same side exist, but the exact pathway is unknown.
Many collaterals from the reticular formation and from the pyramids enter the inferior olivary nucleus.
Removal of one cerebellar hemisphere is followed by atrophy of the opposite olivary nucleus.
Hypertrophy has been associated with
progressive supranuclear palsy.cite journal |author=Hanihara T, Amano N, Takahashi T, Itoh Y, Yagishita S |title=Hypertrophy of the inferior olivary nucleus in patients with progressive supranuclear palsy |journal= Eur. Neurol.|volume=39 |issue=2 |pages=97–102 |year=1998 |pmid=9520070 |doi= |url=http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=ene39097]
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