- Aminohippuric acid
Aminohippurate Systematic (IUPAC) name 2-[(4-Aminobenzoyl)amino]acetic acid Clinical data Pregnancy cat. ? Legal status ? Identifiers CAS number
94-16-6 (sodium salt)
ATC code V04 PubChem DrugBank ChemSpider UNII KEGG ChEBI ChEMBL Synonyms PAH, PAHA, Aminohippurate, 4-Aminohippuric acid , N-(4-Aminobenzoyl)glycine, para-Aminohippurate Chemical data Formula C9H10N2O3 Mol. mass 194.19 g/mol SMILES & (what is this?)
Aminohippuric acid or para-aminohippuric acid (PAH), a derivative of hippuric acid, is a diagnostic agent useful in medical tests involving the kidney used in the measurement of renal plasma flow. It is an amide derivative of the amino acid glycine and para-aminobenzoic acid.
PAH is useful for the measurement of renal plasma flow because it is secreted primarily by the renal tubules; only 20-30% is filtered by the glomerulus. PAH is completely filtered from plasma in the nephron and not reabsorbed by the tubules, in a manner identical to inulin. PAH differs from inulin in that the fraction of PAH that bypasses the glomerulus and enters the nephron's tubular cells (via the peritubular capillaries) is completely secreted. Thus, renal clearance of PAH is useful in calculation of renal plasma flow (RPF), which empirically is (1 − hematocrit) × renal blood flow. Of note, the clearance of PAH is reflective only of RPF to portions of the kidney that deal with urine formation, and thus underestimates actual RPF by about 10%.
The renal extraction ratio of PAH in a normal individual is approximately 0.92.
Aminohippuric acid is often used as the sodium salt sodium para-aminohippurate. During World War II, para-aminohippurate was given along with penicillin in order to prolong the time penicillin circulated in the blood. Because both penicillin and para-aminohippurate compete for the same transporter in the kidney, administering para-aminohippurate with penicillin decreased the clearance of penicillin from the body by the kidney, providing better antibacterial therapy. Transporters found in the kidney eliminate organic anions and cations from the blood by moving substances, in this case, drug metabolites, from blood into urine.
pKa = 3.83
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Diagnostic agents (V04) Digestive systemFat absorptionVitamin A concentratesExocrine pancreatic function Endocrine systemPituitary function Tuberculosis Renal function Urinary system, physiology: renal physiology and acid-base physiology Filtration Hormones affecting filtration Secretion/clearancePharmacokinetics · Clearance of medications · Urine flow rate Reabsorption Endocrine Assessing Renal function/
Measures of dialysis
Acid-base physiology Buffering/compensation Other
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