Bentiromide

"Chymex" redirects here. For the human body digestive fluid, see Chyme.

Bentiromide[1]
IUPAC name 4-[2-benzamido-3- (4-hydroxyphenyl)- propanoyl] aminobenzoic acid
Other names (S)-4-((2-(benzoylamino)-3-(4-hydroxyphenyl) -1-oxopropyl)amino)benzoic acid (S)-p-(α-benzamido-p-hydroxyhydrocinnamamido) benzoic acid BRN 2910938 Benzoyltyrosyl-p-aminobenzoic acid (Btpaba) C12779 CHEMBANK2959 Chymex D01346 N-benzoyl-L-tyrosyl-p-aminobenzoic acid P-((N-benzoyl-L-tyrosin)amido)benzoic acid PFD PFT Ro 11-7891
Identifiers
Abbreviations	Btpaba
CAS number	37106-97-1 Y
PubChem	6957673
ChemSpider	5329364 Y
UNII	239IF5W61J Y
EC number	253-349-8
ChEBI	CHEBI:31263 Y
ChEMBL	CHEMBL1200368 N
ATC code	V04CK03
Jmol-3D images	Image 1
SMILES O=C(O)c1ccc(cc1)NC(=O)[C@@H](NC(=O)c2ccccc2)Cc3ccc(O)cc3
InChI InChI=1S/C23H20N2O5/c26-19-12-6-15(7-13-19)14-20(25-21(27)16-4-2-1-3-5-16)22(28)24-18-10-8-17(9-11-18)23(29)30/h1-13,20,26H,14H2,(H,24,28)(H,25,27)(H,29,30)/t20-/m0/s1 Y Key: SPPTWHFVYKCNNK-FQEVSTJZSA-N Y InChI=1/C23H20N2O5/c26-19-12-6-15(7-13-19)14-20(25-21(27)16-4-2-1-3-5-16)22(28)24-18-10-8-17(9-11-18)23(29)30/h1-13,20,26H,14H2,(H,24,28)(H,25,27)(H,29,30)/t20-/m0/s1 Key: SPPTWHFVYKCNNK-FQEVSTJZBR
Properties
Molecular formula	C23H20N2O5
Molar mass	404.4153
Pharmacology
DrugBank	APRD00818
Supplementary data page
Structure and properties	n, εr, etc.
Thermodynamic data	Phase behaviour Solid, liquid, gas
Spectral data	UV, IR, NMR, MS
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Bentiromide is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. It is given by mouth as a noninvasive test. The amount of 4-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas. Headache and gastrointestinal disturbances have been reported in patients taking bentiromide. Bentiromide is not available in the U.S. or Canada (It was withdrawn in the US in October 1996.)

Data

• XLogP=3.201
• tautomers=12
• H_bond_donor=4
• H_bond_acceptor=5

See also

• Chronic pancreatitis

References

1. ^ Bentiromide - Compound Summary, PubChem.

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Benzoic acids Pharmacology stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Villanova (SEPTA Route 100 station) Deane Montgomery Look at other dictionaries: bentiromide — A peptide used in a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. * * * ben·tir·o·mide (ben tērґo mīd) a compound containing p aminobenzoic acid, used in a… …   Medical dictionary bentiromide test — (for pancreatic function) bentiromide is administered orally and its cleavage into benzoyl tyrosyl and p aminobenzoic acid is monitored as a measure of pancreatic production of chymotrypsin …   Medical dictionary test — 1. To prove; to try a substance; to determine the chemical nature of a substance by means of reagents. 2. A method of examination, as to determine the presence or absence of a definite disease or of some substance in any of the fluids, tissues,… …   Medical dictionary Magnesium sulfate — Anhydrous magnesium sulfate Epsomite (heptahydrate) …   Wikipedia Metyrapone — Systematic (IUPAC) name 2 methyl 1,2 di(pyridin 3 yl)propan 1 one Clinical data Trade names Metopirone …   Wikipedia ATC code V04 — A section of the Anatomical Therapeutic Chemical Classification System.V VariousV04B Urine testsV04C Other diagnostic agentsV04CA Tests for diabetes:V04CA01 Tolbutamide:V04CA02 GlucoseV04CB Tests for fat absorption:V04CB01 Vitamin A… …   Wikipedia Tolbutamide — Systematic (IUPAC) name N [(butylamino)carbonyl] 4 methylbenzenesulfonamide Clinical data AHFS/Drugs.com …   Wikipedia Aminohippuric acid — Aminohippurate Systematic (IUPAC) name 2 [(4 Aminobenzoyl)amino]acetic acid Clinical data Pregnancy cat.  ? …   Wikipedia Ceruletide — Systematic (IUPAC) name (3S) 3 {[(1S) 1 carbamoyl 2 phenylethyl]carbamoyl} 3 [(2S) 2 [(2S) 2 {2 [(3R) 2 [(2S) 2 [(2S) 2 [(2S) 4 carbamoyl 2 {[(2S) 5 oxopyrrolidin 2 yl]formamido}butanamido] 3 carboxypropanamido] 3 [4 (sulfooxy)ph …   Wikipedia Chymex — Chy·mex (kiґməks) trademark for a preparation of bentiromide …   Medical dictionary 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”