- Nucleoside phosphotransferase
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nucleoside phosphotransferase Identifiers EC number 2.7.1.77 CAS number 9055-37-2 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a nucleoside phosphotransferase (EC 2.7.1.77) is an enzyme that catalyzes the chemical reaction
- a nucleotide + a 2'-deoxynucleoside a nucleoside + a 2'-deoxynucleoside 5'-phosphate
Thus, the two substrates of this enzyme are nucleotide and 2'-deoxynucleoside, whereas its two products are nucleoside and 2'-deoxynucleoside 5'-phosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is nucleotide:nucleoside 5'-phosphotransferase. Other names in common use include nonspecific nucleoside phosphotransferase, and nucleotide:3'-deoxynucleoside 5'-phosphotransferase.
References
- Brunngraber EF, Chargaff E (1967). "Purification and properties of a nucleoside phosphotransferase from carrot". J. Biol. Chem. 242 (20): 4834–40. PMID 6061424.
- Prasher DC, Carr MC, Ives DH, Tsai TC, Frey PA (1982). "Nucleoside phosphotransferase from barley. Characterization and evidence for ping pong kinetics involving phosphoryl enzyme". J. Biol. Chem. 257 (9): 4931–9. PMID 6279651.
Transferases: phosphorus-containing groups (EC 2.7) 2.7.1-2.7.4:
phosphotransferase/kinase
(PO4)Hexo- · Gluco- · Fructo- (Hepatic) · Galacto- · Phosphofructo- (1, Liver, Muscle, Platelet, 2) · Riboflavin · Shikimate · Thymidine (ADP-thymidine) · NAD+ · Glycerol · Pantothenate · Mevalonate · Pyruvate · Deoxycytidine · PFP · Diacylglycerol · Phosphoinositide 3 (Class I PI 3, Class II PI 3) · Sphingosine · Glucose-1,6-bisphosphate synthase2.7.2: COOH acceptor2.7.6: diphosphotransferase
(P2O7)2.7.7: nucleotidyltransferase
(PO4-nucleoside)DNA-directed DNA polymerase: DNA polymerase I · DNA polymerase II · DNA polymerase III holoenzyme
DNA nucleotidylexotransferase/Terminal deoxynucleotidyl transferase
RNA-directed DNA polymerase: Reverse transcriptase (Telomerase)RNA nucleotidyltransferaseRNA polymerase/DNA-directed RNA polymerase: RNA polymerase I · RNA polymerase II · RNA polymerase III · RNA polymerase IV · Primase · RNA-dependent RNA polymerase
PNPaseUridylyltransferaseGlucose-1-phosphate uridylyltransferase · Galactose-1-phosphate uridylyltransferaseGuanylyltransferasemRNA capping enzymeOther2.7.8: miscellaneous PhosphatidyltransferasesCDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase · CDP-diacylglycerol—serine O-phosphatidyltransferase · CDP-diacylglycerol—inositol 3-phosphatidyltransferase · CDP-diacylglycerol—choline O-phosphatidyltransferaseGlycosyl-1-phosphotransferase2.7.10-2.7.13: protein kinase
(PO4; protein acceptor)see tyrosine kinasessee serine/threonine-specific protein kinases2.7.12: protein-dual-specificitysee serine/threonine-specific protein kinases2.7.13: protein-histidineThis enzyme-related article is a stub. You can help Wikipedia by expanding it.