Nucleoside phosphotransferase

Nucleoside phosphotransferase
nucleoside phosphotransferase
Identifiers
EC number 2.7.1.77
CAS number 9055-37-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a nucleoside phosphotransferase (EC 2.7.1.77) is an enzyme that catalyzes the chemical reaction

a nucleotide + a 2'-deoxynucleoside \rightleftharpoons a nucleoside + a 2'-deoxynucleoside 5'-phosphate

Thus, the two substrates of this enzyme are nucleotide and 2'-deoxynucleoside, whereas its two products are nucleoside and 2'-deoxynucleoside 5'-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is nucleotide:nucleoside 5'-phosphotransferase. Other names in common use include nonspecific nucleoside phosphotransferase, and nucleotide:3'-deoxynucleoside 5'-phosphotransferase.

References

  • Brunngraber EF, Chargaff E (1967). "Purification and properties of a nucleoside phosphotransferase from carrot". J. Biol. Chem. 242 (20): 4834–40. PMID 6061424. 
  • Prasher DC, Carr MC, Ives DH, Tsai TC, Frey PA (1982). "Nucleoside phosphotransferase from barley. Characterization and evidence for ping pong kinetics involving phosphoryl enzyme". J. Biol. Chem. 257 (9): 4931–9. PMID 6279651.