Nucleoside phosphotransferase

nucleoside phosphotransferase
Identifiers
EC number	2.7.1.77
CAS number	9055-37-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a nucleoside phosphotransferase (EC 2.7.1.77) is an enzyme that catalyzes the chemical reaction

a nucleotide + a 2'-deoxynucleoside $\rightleftharpoons$ a nucleoside + a 2'-deoxynucleoside 5'-phosphate

Thus, the two substrates of this enzyme are nucleotide and 2'-deoxynucleoside, whereas its two products are nucleoside and 2'-deoxynucleoside 5'-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is nucleotide:nucleoside 5'-phosphotransferase. Other names in common use include nonspecific nucleoside phosphotransferase, and nucleotide:3'-deoxynucleoside 5'-phosphotransferase.

References

• Brunngraber EF, Chargaff E (1967). "Purification and properties of a nucleoside phosphotransferase from carrot". J. Biol. Chem. 242 (20): 4834–40. PMID 6061424. 
• Prasher DC, Carr MC, Ives DH, Tsai TC, Frey PA (1982). "Nucleoside phosphotransferase from barley. Characterization and evidence for ping pong kinetics involving phosphoryl enzyme". J. Biol. Chem. 257 (9): 4931–9. PMID 6279651. 

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