Nucleoside-phosphate kinase

nucleoside phosphate kinase
Identifiers
EC number	2.7.4.4
CAS number	9026-50-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a nucleoside-phosphate kinase (EC 2.7.4.4) is an enzyme that catalyzes the chemical reaction

ATP + nucleoside phosphate $\rightleftharpoons$ ADP + nucleoside diphosphate

Thus, the two substrates of this enzyme are ATP and nucleoside phosphate, whereas its two products are ADP and nucleoside diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:nucleoside-phosphate phosphotransferase. This enzyme is also called NMP-kinase. This enzyme participates in pyrimidine metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2BND, 2BNE, and 2BNF.

References

• AYENGAR P, GIBSON DM, SANADI DR (1956). "Transphosphorylations between nucleoside phosphates". Biochim. Biophys. Acta. 21 (1): 86–91. doi:10.1016/0006-3002(56)90096-8. PMID 13363863. 
• HEPPEL LA, STROMINGER JL, MAXWELL ES (1959). "Nucleoside monophosphate kinases. II. Transphosphorylation between adenosine monophosphate and nucleoside triphosphates". Biochim. Biophys. Acta. 32: 422–30. doi:10.1016/0006-3002(59)90615-8. PMID 14401179. 
• LIEBERMAN I, KORNBERG A, SIMMS ES (1955). "Enzymatic synthesis of nucleoside diphosphates and triphosphates". J. Biol. Chem. 215 (1): 429–40. PMID 14392176. 
• Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 139-149.

This enzyme-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Enzyme stubs EC 2.7.4 Enzymes of known structure Wikimedia Foundation. 2010. Игры ⚽ Нужна курсовая? National champions 5000 metres (women) Hog Island (California) Look at other dictionaries: nucleoside-phosphate kinase — nu·cleo·side phos·phate ki·nase (nooґkle o sīd fosґfat kiґnās) [EC 2.7.4.4] any enzyme of the transferase class that catalyzes the transfer of a phosphate from ATP to a nucleoside phosphate to form a nucleoside diphosphate. The reaction …   Medical dictionary (deoxy)nucleoside-phosphate kinase — In enzymology, a (deoxy)nucleoside phosphate kinase (EC number|2.7.4.13) is an enzyme that catalyzes the chemical reaction:ATP + deoxynucleoside phosphate ightleftharpoons ADP + deoxynucleoside diphosphateThus, the two substrates of this enzyme… …   Wikipedia Nucleoside-diphosphate kinase — Nucleoside diphosphate kinases (NDKs, also NDP Kinase, (poly)nucleotide kinases and nucleoside diphosphokinases) are enzymes that catalyze the exchange of phosphate groups between different nucleoside diphosphates. NDK activities maintain an… …   Wikipedia nucleoside-diphosphate kinase — nu·cleo·side di·phos·phate ki·nase (nooґkle o sīd diґfos fāt kiґnās) [EC 2.7.4.6] 1. an enzyme of the transferase class with broad specificity that catalyzes the reversible transfer of a phosphate from ATP to a nucleoside… …   Medical dictionary Nucleoside phosphotransferase — Identifiers EC number 2.7.1.77 CAS number 9055 37 2 …   Wikipedia Nucleoside diphosphate kinases — Nucléoside diphosphate kinases Les nucléoside diphosphate kinases (NDKs, aussi NDPKs) sont des enzymes qui catalysent l échange d un groupement phosphate entre différents nucléoside diphosphates. Comme le cycle de Krebs produit seulement de l ATP …   Wikipédia en Français Nucleoside phosphorylase — Nucleoside phosphorylase, also known as NP, is a human gene.cite web | title = Entrez Gene: NP nucleoside phosphorylase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=4860| accessdate = ] PBB Summary… …   Wikipedia Nucleoside-triphosphate—adenylate kinase — Identifiers EC number 2.7.4.10 CAS number 9026 74 8 …   Wikipedia Nucléoside diphosphate kinases — Les nucléoside diphosphate kinases (NDKs, aussi NDPKs) sont des enzymes qui catalysent l échange d un groupement phosphate entre différents nucléoside diphosphates. Comme le cycle de Krebs produit seulement de l ATP, la NDP kinase sert à… …   Wikipédia en Français kinase — /kuy nays, nayz, kin ays, ayz/, n. Biochem. a transferase that catalyzes the phosphorylation of a substrate by ATP. [1900 05; KIN(ETIC) + ASE] * * * ▪ enzyme  an enzyme that adds phosphate groups (PO43−) to other molecules. A large number of… …   Universalium 18+ © Academic, 2000-2025 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”