Nucleoside-triphosphate-adenylate kinase

Nucleoside-triphosphate-adenylate kinase

In enzymology, a nucleoside-triphosphate-adenylate kinase (EC number| is an enzyme that catalyzes the chemical reaction

:nucleoside triphosphate + AMP ightleftharpoons nucleoside diphosphate + ADP

Thus, the two substrates of this enzyme are nucleoside triphosphate and AMP, whereas its two products are nucleoside diphosphate and ADP.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is nucleoside-triphosphate:AMP phosphotransferase. Other names in common use include guanosine triphosphate-adenylate kinase, nucleoside triphosphate-adenosine monophosphate transphosphorylase, GTP:AMP phosphotransferase, and isozyme 3 of adenylate kinase. This enzyme participates in pyrimidine metabolism.

tructural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|1ZD8 and PDB link|2AK3.



External links

::"The CAS registry number for this enzyme class is CAS registry|9026-74-8."

Gene Ontology (GO) codes

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