CAS number 51481-10-8 YesY
PubChem 40024
ChemSpider 36584 YesY
KEGG C09747 YesY
Jmol-3D images Image 1
Molecular formula C15H20O6
Molar mass 296.32 g mol−1
MSDS External MSDS
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Vomitoxin, also known as deoxynivalenol (DON), is a type B trichothecene, an epoxy-sesquiterpeneoid. This mycotoxin occurs predominantly in grains such as wheat, barley, oats, rye, and maize, and less often in rice, sorghum, and triticale. The occurrence of deoxynivalenol is associated primarily with Fusarium graminearum (Gibberella zeae) and F. culmorum, both of which are important plant pathogens which cause Fusarium head blight in wheat and Gibberella ear rot in maize. A direct relationship between the incidence of Fusarium head blight and contamination of wheat with deoxynivalenol has been established [1]. The incidence of Fusarium head blight is strongly associated with moisture at the time of flowering (anthesis), and the timing of rainfall, rather than the amount, is the most critical factor. However, increased amount of moisture towards harvest time has been associated with lower amount of vomitoxin in wheat grain due to leaching of toxins [2] Furthermore, deoxynivalenol contents are significantly affected by the susceptibility of cultivars towards Fusarium species, previous crop, tillage practices, and fungicide use [3]

F. graminearum grows optimally at a temperature of 25 °C and at a water activity above 0.88. F. culmorum grows optimally at 21 °C and at a water activity above 0.87. The geographical distribution of the two species appears to be related to temperature, F. graminearum being the commoner species and occurring in warmer climates. Deoxynivalenol has been implicated in incidents of mycotoxicoses in both humans and farm animals.

When compared to other trichothecene mycotoxins which can form in grains and forages, vomitoxin is relatively mild. Reduced feed intake, and the accompanying decrease in performance, are the only symptoms of vomitoxin toxicity livestock producers will likely encounter. This response to vomitoxin appears to occur through the central nervous system. Vomitoxin belongs to a class of mycotoxins (tricothecenes) which are strong protein inhibitors. Inhibition of protein synthesis following exposure to vomitoxin causes the brain to increase its uptake of the amino acid tryptophan and, in turn, its synthesis of serotonin. Increased levels of serotonin are believed to be responsible for the anorexic effects of DON and other tricothecenes. Irritation of the gastrointestinal tract may also play a role in reducing feed intake... This fact may also partially explain the high incidence of paraesophageal stomach ulcers observed in sows off feed during feed refusal.

  • Human foods: Vomitoxin is not a known carcinogen as with aflatoxin. Large amounts of grain with vomitoxin would have to be consumed to pose a health risk to humans. The U.S. Food and Drug Administration has established a level of 1 ppm (parts per million) restriction of vomitoxin.
  • Companion animals: Dogs and cats are restricted to 5 ppm and of grains and grain byproducts and that the grains not exceed 40% percent of the diet.
  • Livestock and farm animals: In animals and livestock, vomitoxin causes a refusal to feed and lack of weight gain when fed above advised levels. Restrictions are set at 10 ppm for poultry and ruminating beef and feedlot cattle older than 4 months. Ingredients may not exceed 50% of the animal's diet. Dairy cow limits are set at 2 ppm.


  1. ^ Gautam, P. and Dill-Macky, R. 2011. Type I host resistance and Trichothecene Accumulation in Fusarium-infected Wheat Heads. American Journal of Agricultural and Animal Sciences 6(2):231-241. [1]
  2. ^ Gautam, P. and Dill-Macky, R. 2012. Impact of moisture, host genetics and Fusarium graminearum isolates on Fusarium head blight development and trichothecene accumulation in spring wheat. Mycotoxin Research 28 (1) DOI: 10.1007/s12550-011-0115-6 [2]
  3. ^ Beyer M, Klix MB, Klink H, Verreet J-A (2006): Quantifying the effects of previous crop, tillage, cultivar and triazole fungicides on the deoxynivalenol content of wheat grain – a review. Journal of Plant Diseases and Protection 113: 241–246. [3]

External links

Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • Vomitoxin — Strukturformel Allgemeines Name Deoxynivalenol Andere Namen DON Vomitoxin 12,13 Epoxy 3,4,15 trihydroxy tr …   Deutsch Wikipedia

  • vomitoxin — vom·i·tox·in (vomґĭ tok″sin) deoxynivalenol …   Medical dictionary

  • List of chemical compounds with unusual names — Chemical nomenclature, replete as it is with compounds with complex names, is a repository for some very peculiar and sometimes startling names. A browse through the Physical Constants of Organic Compounds in the CRC Handbook of Chemistry and… …   Wikipedia

  • Natural Balance Pet Foods — Type Private Industry Pet food Founded Pacoima …   Wikipedia

  • Deoxynivalenol — Strukturformel Allgemeines Name Deoxynivalenol Andere Namen …   Deutsch Wikipedia

  • Toxin — This article is about the class of poisonous substances. For other uses, see Toxin (disambiguation). Universal warning symbol used to indicate toxic substances or environments A toxin (from Ancient Greek: τοξικόν toxikon) is a poisonous… …   Wikipedia

  • Botulinum toxin — Clinical data Pregnancy cat.  ? Legal status  ? (US) Rout …   Wikipedia

  • Don — or DON may refer to Contents 1 People 2 Chemistry 3 Geography 4 …   Wikipedia

  • Neurotoxin — A neurotoxin is a toxin that acts specifically on nerve cells[1] (neurons), usually by interacting with membrane proteins such as ion channels. Some sources are more general, and define the effect of neurotoxins as occurring at nerve tissue.[2]… …   Wikipedia

  • Lipopolysaccharide — Structure of a lipopolysaccharide Lipopolysaccharides (LPS), also known as lipoglycans, are large molecules consisting of a lipid and a polysaccharide joined by a covalent bond; they are found in the outer membrane of Gram negative bacteria, act… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”