Fumonisin B1

Fumonisin B1

Chembox new
Name = Fumonisin B1
ImageFile = Fumonisin B1.svg
ImageName = Fumonisin B1
OtherNames = Macrofusine
Section1 = Chembox Identifiers
CASNo = 116355-83-0
Section2 = Chembox Properties
Formula = C34H59NO15
MolarMass = 721.8
Appearance = White to off-white powder

Fumonisine B1 is an inhibitor of ceramide synthase.

Fumonisin B1 is the most prevalent member of a family of toxins produced by several species of Fusarium moulds which occur mainly in maize. Fumonisin B1 contamination of maize has been reported worldwide at mg/kg levels. Human exposure occurs at levels of micrograms to milligrams per day and is greatest in regions where maize products are the dietary staple.

Fumonisin B1 is hepatotoxic and nephrotoxic in all animal species tested. The earliest histological change to appear in either the liver or kidney of fumonisin-treated animals is increased apoptosis followed by regenerative cell proliferation. While the acute toxicity of fumonisin is low, it is the known cause of two diseases which occur in domestic animals with rapid onset: equine leukoencephalomalacia and porcine pulmonary oedema syndrome. Both of these diseases involve disturbed sphingolipid metabolism and cardiovascular dysfunction.

References

External links

* [http://www.romerlabs.com/mycotoxins.html Detailed information about mycotoxins]
* [http://www.inchem.org/documents/iarc/vol82/82-05.html International Agency for Research on Cancer (IARC)- Good review on Fumonisin B1]

*http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/212211.htm&word=leukoencephalomalacia


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