Calciseptine

Calciseptine

Calciseptine (CaS) is a natural neurotoxin isolated from the black mamba "Dendroaspis p. polylepis" venom. This toxin consists of 60 amino acids with four disulfide bonds. Calciseptine specifically blocks L-Type calcium channels, but not other voltage-dependent Ca2+ channels such as N-type and T-type channels. De Weille, J. R., Schweitz, H., Maes, P., Tartar, A. & Lazdunski, M. Proc. Natl. Acad. Sci. USA 88, "1991" 2437-2440.]

Sequence

Its amino acid sequence is: RICYI HKASL PRATK TCVEN TCYKM FIRTQ REYIS REGCG CPTAM WPYQT ECCKG DRCNK

Isolation

Calciseptine is purified from the venom of black mamba "Dendroaspis p. polyepsis" via three isolation steps: (1) gel filtration, (2) ion exchange on TSK SP 5PW, and (3) reverse-phase chromatograghy on RP18. It represents 2.8% of the total venom components. Schweitz, H., Bidard, J.-N. & Lazdunski, M. Toxicon 1990, "18", 847-856.]

Target

Calciseptine blocks L-type Ca2+ channels. De Weille, J. R., Schweitz, H., Maes, P., Tartar, A. & Lazdunski, M. Proc. Natl. Acad. Sci. USA 88, "1991" 2437-2440.] As a result, it blocks spontaneous contractions of rat portal vein, contractions of the rat thoracic aorta, uterus and cardiac preparations.

References


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • calciseptine — Polypeptide toxin (60 residues) from Dendroaspis polylepis. Specific blocker of some L type calcium channels that will cause relaxation of smooth muscle and inhibition of cardiac muscle but has no effect on skeletal muscle …   Dictionary of molecular biology

  • Black mamba — For other uses, see Black mamba (disambiguation). Black mamba Conservation status …   Wikipedia

  • Neurotoxin — A neurotoxin is a toxin that acts specifically on nerve cells[1] (neurons), usually by interacting with membrane proteins such as ion channels. Some sources are more general, and define the effect of neurotoxins as occurring at nerve tissue.[2]… …   Wikipedia

  • Toxin — This article is about the class of poisonous substances. For other uses, see Toxin (disambiguation). Universal warning symbol used to indicate toxic substances or environments A toxin (from Ancient Greek: τοξικόν toxikon) is a poisonous… …   Wikipedia

  • Botulinum toxin — Clinical data Pregnancy cat.  ? Legal status  ? (US) Rout …   Wikipedia

  • Lipopolysaccharide — Structure of a lipopolysaccharide Lipopolysaccharides (LPS), also known as lipoglycans, are large molecules consisting of a lipid and a polysaccharide joined by a covalent bond; they are found in the outer membrane of Gram negative bacteria, act… …   Wikipedia

  • Psychoactive toad — is a name used for toads from which psychoactive substances from the family of bufotoxins can be derived. The skin and poison of Bufo alvarius (Colorado River toad or Sonoran Desert toad) contain 5 MeO DMT and bufotenin. Other species contain… …   Wikipedia

  • Mamba — For other uses, see Mamba (disambiguation). Dendroaspis Black Mamba Scientific classification Kingdom …   Wikipedia

  • Mycotoxin — A mycotoxin (from Greek μύκης (mykes, mukos) “fungus” and Latin (toxicum) “poison”)[1][2] is a toxic secondary metabolite produced by organisms of the fungus kingdom, commonly known as molds.[3][4] The term ‘mycotoxin’ is usually reserved for the …   Wikipedia

  • Charybdotoxin — Refined model of Charybdotoxin[1] Identifiers Symbol  ? …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”