Myocardial stunning

Myocardial stunning
Classification and external resources
MeSH	D017682

Myocardial stunning is the reversible reduction of function of heart contraction^[1] after reperfusion not accounted for by tissue damage or reduced blood flow.^[2]

After total ischemia occurs, the myocardium switches immediately form aerobic glycolysis to anaerobic glycolysis resulting in the reduced ability to produce high energy phosphates such as ATP and Creatinine Phosphate. At this point, the lack of the energy and lactate accumulation results in cessation of contraction within 60 seconds of ischemia (i.e. Vessel Occlusion). Subsequent to this is a period of "myocardial stunning," in which reversible ischemic damage is taking place. At approximately 30 minutes after the onset of total ischemia the damage becomes irreversible, thereby ending the phase of myocardial stunning.

References

1. ^ MeSH Myocardial+Stunning
2. ^ Grund F (February 2001). "[Three cardiac mysteries--stunning, hibernation and ischemic preconditioning]" (in Norwegian). Tidsskr. Nor. Laegeforen. 121 (4): 440–4. PMID 11255859. 

External links

• "Myocardial “stunning” in man"
• Baker C, Rimoldi O, Camici P, Barnes E, Chacon M, Huehns T, Haskard D, Polak J, Hall R (1999). "Repetitive myocardial stunning in pigs is associated with the increased expression of inducible and constitutive nitric oxide synthases.". Cardiovasc Res 43 (3): 685–97. doi:10.1016/S0008-6363(99)00149-2. PMID 10690340. 
• Wittstein IS, Thiemann DR, Lima JA et al. (February 2005). "Neurohumoral features of myocardial stunning due to sudden emotional stress". N. Engl. J. Med. 352 (6): 539–48. doi:10.1056/NEJMoa043046. PMID 15703419. http://content.nejm.org/cgi/pmidlookup?view=short&pmid=15703419&promo=ONFLNS19.