Torsades de pointes

Infobox_Disease
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Caption =
DiseasesDB = 29252
ICD10 =
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MedlinePlus =
eMedicineSubj = med
eMedicineTopic = 2286
eMedicine_mult = eMedicine2|emerg|596 | MeshID = D016171

Torsades de pointes, torsades or torsade de pointes is a French term that literally means "twisting of the points". It was first described by Dessertenne in 1966 [cite journal |author=Dessertenne F |title=La tachycardie ventriculaire a deux foyers opposes variables. |language=French |journal=Arch Mal Coeur Vaiss. |volume=59 |issue=2 |pages=263–72 |year=1966 |pmid=4956181 |doi=] and refers to a specific variety of ventricular tachycardia that exhibits distinct characteristics on the electrocardiogram (ECG).

Presentation

The ECG reading in torsades demonstrates a rapid, polymorphic ventricular tachycardia with a characteristic twist of the QRS complex around the isoelectric baseline. It is also associated with a fall in arterial blood pressure, which can produce fainting. Although torsade is a rare ventricular arrhythmia, it can degenerate into ventricular fibrillation, which will lead to sudden death in the absence of medical intervention. Torsade de pointes is associated with long QT syndrome, a condition whereby prolonged QT intervals are visible on the ECG.

Causes

Long QT syndrome can either be inherited as congenital mutations of ion channels carrying the cardiac impulse/action potential or acquired as a result of drugs that block these cardiac ion currents.

Common causes for torsades de pointes include diarrhea, hypomagnesemia and hypokalemia. It is commonly seen in malnourished individuals and chronic alcoholics. Drug interactions such as erythromycin or moxifloxacin, taken concomitantly with inhibitors like nitroimidazole, dietary supplements, and various medications like methadone, lithium, tricyclic antidepressants or phenothiazines may also contribute.

Factors that are associated with an increased tendency toward torsades de pointes include:
* Familial long QT syndrome
* Class IA antiarrhythmics
* Class III antiarrhythmics
* Hypomagnesemia
* Hypokalemia
* Hypocalcemia
* Hypoxia
* Acidosis
* Heart failure
* Left ventricular hypertrophy
* Slow heart rate
* Female gender
* Hypothermia
* Subarachnoid hemorrhage

Treatment

Treatment is directed at withdrawal of the offending agent, infusion of magnesium sulfate, antiarrhythmic drugs, and electrical therapy as needed. Because of the polymorphic nature of torsades de pointes, synchronized cardioversion may not be possible, and the patient may require an unsynchronized shock (or defibrillation).

History and terminology

The French term is largely due to the fact that the phenomenon was originally described in a French medical journal by Dessertenne in 1966, when he observed this rhythm disorder in an 80-year-old female patient with complete intermittent atrioventricular block.

References