Plasmacytoma

Plasmacytoma
See also: Multiple myeloma
Plasmacytoma
Classification and external resources

Micrograph of a plasmacytoma. H&E stain.
ICD-10 C90.2
ICD-9 238.6
ICD-O: M9731/3, M9734/3
DiseasesDB 8628
eMedicine med/2532
MeSH D010954

Plasmacytoma refers to a malignant plasma cell tumor[1] growing within soft tissue or within the skeleton. The skeletal forms usually have other occult tumors and frequently disseminate to multiple myeloma over the course of 5–10 years. The soft tissue forms most often occur in the upper respiratory tract, rarely disseminate, and are cured by resection. Most but not all cases produce paraproteinemia. Solitary tumors in bone can be treated by radiotherapy.

Contents

Terminology

There can be some ambiguity when using the word.

"Plasmacytoma" is sometimes equated with "plasma cell dyscrasia" or "solitary myeloma".[2]

It is often used as part of the phrase "solitary plasmacytoma".[3][4][5]

It is also used as part of the phrase "extramedullary plasmacytoma ".[6][7] In this context, "extramedullary" means outside of the bone marrow.

Diagnosis

It is diagnosed by immunoglobulin electrophoresis (or Serum protein electrophoresis) and bone marrow biopsy. Immunoglobulin electrophoresis will show a monoclonal M spike, but bone marrow biopsy will fail to find the classical signs of multiple myeloma. After those two determinations are made, search for the primary site in the soft tissue begins.

Gallery

  • Micrograph of a plasmacytoma.

See also

References

  1. ^ "CRC - Glossary P". http://cll.ucsd.edu/glossaryp.htm. Retrieved 2009-03-02. [dead link]
  2. ^ "plasmacytoma" at Dorland's Medical Dictionary
  3. ^ Dimopoulos MA, Moulopoulos LA, Maniatis A, Alexanian R (September 2000). "Solitary plasmacytoma of bone and asymptomatic multiple myeloma". Blood 96 (6): 2037–44. PMID 10979944. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=10979944. 
  4. ^ Di Micco P, Di Micco B (March 2005). "Up-date on solitary plasmacytoma and its main differences with multiple myeloma". Exp. Oncol. 27 (1): 7–12. PMID 15812350. http://www.exp-oncology.com.ua/en/archives/21/383.html. 
  5. ^ Dingli D, Kyle RA, Rajkumar SV, et al. (September 2006). "Immunoglobulin free light chains and solitary plasmacytoma of bone". Blood 108 (6): 1979–83. doi:10.1182/blood-2006-04-015784. PMC 1895544. PMID 16741249. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=16741249. 
  6. ^ Megat Shiraz MA, Jong YH, Primuharsa Putra SH (November 2008). "Extramedullary plasmacytoma in the maxillary sinus". Singapore Med J 49 (11): e310–1. PMID 19037537. http://smj.sma.org.sg/4911/4911cr6.pdf. 
  7. ^ Bink K, Haralambieva E, Kremer M, et al. (April 2008). "Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics". Haematologica 93 (4): 623–6. doi:10.3324/haematol.12005. PMID 18326524. http://www.haematologica.org/cgi/pmidlookup?view=long&pmid=18326524. 

External links

v · d · eImmune disorders, Immunoproliferative immunoglobulin disorders (D89, 273)
PCDs/PP
Other hypergammaglobulinemia

M: LMC

cell/phys/auag/auab/comp, igrc

imdf/ipig/hyps/tumr

proc, drug(L3/4)
v · d · eHematological malignancy/leukemia histology (ICD-O 9590–9989, C81–C96, 200–208)
Lymphoid/Lymphoproliferative, Lymphomas/Lymphoid leukemias (9590–9739, 9800–9839)
By development/
marker
ALL (Precursor B acute lymphoblastic leukemia/lymphoma)
germinal center/follicular B cell (Follicular, Burkitt's, GCB DLBCL, Primary cutaneous follicular lymphoma)
RS (CD15+, CD30+)
PCDs/PP
(CD38+/CD138+)
see immunoproliferative immunoglobulin disorders
By infection
Diffuse large B-cell lymphoma · Intravascular large B-cell lymphoma · Primary cutaneous marginal zone lymphoma · Primary cutaneous immunocytoma · Plasmacytoma · Plasmacytosis · Primary cutaneous follicular lymphoma
By development/
marker

indolent: Mycosis fungoides · Pagetoid reticulosis · Granulomatous slack skin

aggressive: Sézary's disease · Adult T-cell leukemia/lymphoma
Non-MF

CD30-: Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma · Pleomorphic T-cell lymphoma · Lymphomatoid papulosis type B

CD30+: CD30+ cutaneous T-cell lymphoma · Secondary cutaneous CD30+ large cell lymphoma · Lymphomatoid papulosis type A
Other peripheral
Hepatosplenic · Angioimmunoblastic · Enteropathy-associated T-cell lymphoma · Peripheral T-cell lymphoma-Not-Otherwise-Specified (Lennert lymphoma) · Subcutaneous T-cell lymphoma
By infection
HTLV-1 (Adult T-cell leukemia/lymphoma)
NK cell/
(most CD56)
Aggressive NK-cell leukemia · Blastic NK cell lymphoma
T or NK
EBV (Extranodal NK-T-cell lymphoma/Angiocentric lymphoma) · Large granular lymphocytic leukemia
Lymphoid+myeloid
Cutaneous lymphoid hyperplasia

M: LMC

cell/phys/auag/auab/comp, igrc

imdf/ipig/hyps/tumr

proc, drug(L3/4)



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Look at other dictionaries:

  • plasmacytoma — Malignant tumour of plasma cells, very similar to a myeloma (plasmacytomas usually develop into multiple myeloma). Can easily be induced in rodents by the injection of complete Freund s adjuvant. Plasmacytoma cells are fused with primed… …   Dictionary of molecular biology

  • plasmacytoma — A discrete, presumably solitary mass of neoplastic plasma cells in bone or in one of various extramedullary sites; in humans, such lesions are probably the initial phase of developing plasma cell myeloma. [plasmacyte + G. oma …   Medical dictionary

  • plasmacytoma — n. a malignant tumour of plasma cells, often known as a solitary myeloma . Although usually occurring as a single tumour in bone marrow or more rarely soft tissue (extramedullary plasmacytoma), it may be multiple, in which case it is classified… …   The new mediacal dictionary

  • plasmacytoma — A type of cancer that begins in plasma cells (white blood cells that produce antibodies). A plasmacytoma may turn into multiple myeloma …   English dictionary of cancer terms

  • plasmacytoma — noun A malignant tumour of plasmacytes …   Wiktionary

  • plasmacytoma — plas·ma·cy·to·ma …   English syllables

  • plasmacytoma — noun neoplasm of plasma cells (usually in bone marrow) • Hypernyms: ↑tumor, ↑tumour, ↑neoplasm …   Useful english dictionary

  • Плазмоцитома (Plasmacytoma) — злокачественная опухоль плазматических клеток, по своему происхождению тесно связанная с миеломой. Обычно развивается как одиночная опухоль кости, однако иногда она может быть и множественной. Реже эта опухоль поражает мягкие ткани (обычно… …   Медицинские термины

  • multiple plasmacytoma of bone — multiple myeloma …   Medical dictionary

  • ПЛАЗМОЦИТОМА — (plasmacytoma) злокачественная опухоль плазматических клеток, по своему происхождению тесно связанная с миеломой. Обычно развивается как одиночная опухоль кости, однако иногда она может быть и множественной. Реже эта опухоль поражает мягкие ткани …   Толковый словарь по медицине

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