Reed-Sternberg cell

Reed-Sternberg cell

Reed-Sternberg cells (Lacunar Histiocytes for certain types) are different giant cells found on light microscopy in biopsies from individuals with Hodgkin's lymphoma (aka Hodgkin's disease; a type of lymphoma), and certain other disorders. They are derived from B lymphocytes.

They are named after Dorothy Reed Mendenhall (1874-1964) and Carl Sternberg (1872-1935), who provided the first definitive microscopic descriptions of Hodgkin's disease. [Reed D. On the pathological changes in Hodgkin's disease, with special reference to its relation to tuberculosis. Johns Hopkins Hosp Rep 1902;10:133-96.] [Sternberg C. Uber eine eigenartige unter dem Bilde der Pseudoleukamie verlaufende Tuberculose des lymphatischen Apparates. Ztschr Heilk 1898;19:21-90.]

Reed-Sternberg cells are large and are either multinucleated or have a bilobed nucleus (thus resembling an "owl's eye" appearance) with prominent eosinophilic inclusion-like nucleoli. Reed-Sternberg cells are CD30 and CD15 positive, usually negative for CD20 and CD45. The presence of these cells is not pathognomonic for the diagnosis of classical Hodgkin's lymphoma. They can also be found in reactive lymphadenopathy (such as infectious mononucleosis, carbamazepine associated lymphadenopathy) and rarely non-Hodgkin lymphomas.

External links

* [http://www.lmp.ualberta.ca/resources/pathoimages/Images-R/000p0111.jpgImage]
* [http://thecrookstoncollection.com/v/diseased/neoplasms/hodgkin/ Lacunar Histiocyte]

References


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Look at other dictionaries:

  • Reed-Sternberg cell — A type of cell that appears in patients with Hodgkin s disease. The number of these cells increases as the disease advances. * * * Reed Stern·berg cell rēd stərn bərg n a binucleate or multinucleate acidophilic giant cell found in the tissues in… …   Medical dictionary

  • Reed-Sternberg cell — see Sternberg Reed cell …   The new mediacal dictionary

  • Reed-Sternberg cell — A type of cell that appears in people with Hodgkin disease. The number of these cells increases as the disease advances …   English dictionary of cancer terms

  • Reed-Sternberg cell — Giant histiocytic cells, a common feature of Hodgkin&’s disease …   Dictionary of molecular biology

  • Reed-Sternberg cell — noun A giant lymphocyte characteristic of Hodgkins lymphoma …   Wiktionary

  • Sternberg cell — Stern·berg cell stərn bərg n REED STERNBERG CELL …   Medical dictionary

  • Reed-Sternberg cells — Reed Stern·berg cells (rēdґ stərnґbərg) [D. Reed; Carl von Sternberg, Austrian pathologist, 1872–1935] see under cell …   Medical dictionary

  • Клетка Штернберга-Рид (Stemberg-Reedcell), Клетка Ридштернберга (Reed-Sternberg Cell) — большая двуядерная клетка, обнаруживаемая при болезни Ходжкина. Источник: Медицинский словарь …   Медицинские термины

  • sternberg cell — ˈstərnˌbərg noun also sternberg reed cell ˈrēd Usage: usually capitalized S&R Etymology: after Carl Sternberg died 1935 German pathologist : a multinucleate acidophil giant cell found in the tissues in Hodgkin s disease …   Useful english dictionary

  • Sternberg-Reed cell — n REED STERNBERG CELL * * * (Reed Sternberg cell) a large binucleate cell that is characteristic of Hodgkin s disease. C. Sternberg (1872 1935), Austrian pathologist; D. Reed Mendenhall (1874 1964), US pathologist …   Medical dictionary

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