B-cell prolymphocytic leukemia
- B-cell prolymphocytic leukemia
Infobox_Disease
Name = PAGENAME
Caption = Prolymphocyte
DiseasesDB =
ICD10 =
ICD9 =
ICDO = 9833
OMIM =
MedlinePlus =
eMedicineSubj =
eMedicineTopic =
MeshID =
B-cell prolymphocytic leukemia is a more aggressive, but still treatable, form of chronic lymphocytic leukemia. The malignant B cells are larger than average. The name is commonly abbreviated B-PLL.
It can involve deletions from chromosome 11 and chromosome 13.[cite journal |author=Lens D, Matutes E, Catovsky D, Coignet LJ |title=Frequent deletions at 11q23 and 13q14 in B cell prolymphocytic leukemia (B-PLL) |journal=Leukemia |volume=14 |issue=3 |pages=427–30 |year=2000 |pmid=10720137 |doi=] ]It has a relatively poor prognosis.[cite journal |author=Del Giudice I, Davis Z, Matutes E, "et al" |title=IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL) |journal=Leukemia |volume=20 |issue=7 |pages=1231–7 |year=2006 |pmid=16642047 |doi=10.1038/sj.leu.2404238] ]A case has been described as CD20+, CD22+, and CD5-.[cite journal |author=Yamamoto K, Hamaguchi H, Nagata K, Shibuya H, Takeuchi H |title=Splenic irradiation for prolymphocytic leukemia: is it preferable as an initial treatment or not? |journal=Jpn. J. Clin. Oncol. |volume=28 |issue=4 |pages=267–9 |year=1998 |month=April |pmid=9657013 |doi= |url=http://jjco.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=9657013] ]References
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