- Nodular sclerosis
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Nodular sclerosis Classification and external resources ICD-10 C81.1 ICD-9 201.5 ICD-O: M9663/3-9667/3 Nodular sclerosis (or "NSHL") is a form of Hodgkin's lymphoma[1] that is the most common subtype of HL in developed countries. It affects females and males equally and has a median age of onset at ~28 years. It is composed of large tumor nodules with lacunar Reed-Sternberg cell (RS cells) surrounded by fibrotic collagen bands.
The British National Lymphoma Investigation further categorized NSHL based upon Reed-Sternberg cells into "nodular sclerosis type I" (NS I) and "nodular sclerosis type II" (NS II), with the first subtype responding better to treatment. [2]
References
- ^ Falchi L, Capello D, Palumbo B, et al. (November 2007). "A case of nodular sclerosis Hodgkin's lymphoma repeatedly relapsing in the context of composite plasma cell-hyaline vascular Castleman's disease: successful response to rituximab and radiotherapy". Eur. J. Haematol. 79 (5): 455–61. doi:10.1111/j.1600-0609.2007.00952.x. PMC 2121125. PMID 17908180. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2121125.
- ^ Mauch, Peter; James Armitage, Volker Diehl, Richard Hoppe, Laurence Weiss (1999). Hodgkin's Disease. Lippincott Williams & Wilkins. p. 107. ISBN 0-7817-1502-4.
External links
- Illustration, at UMDNJ
- Illustration
- PubMed - use of Erythropoietin
- Subtypes
- Lymphoma Association information on nodular sclerosing
Hematological malignancy/leukemia histology (ICD-O 9590–9989, C81–C96, 200–208)
Lymphoid/Lymphoproliferative, Lymphomas/Lymphoid leukemias (9590–9739, 9800–9839)By development/
markerALL (Precursor B acute lymphoblastic leukemia/lymphoma)CD5+CD22+germinal center/follicular B cell (Follicular, Burkitt's, GCB DLBCL, Primary cutaneous follicular lymphoma)marginal zone/marginal-zone B cell (Splenic marginal zone, MALT, Nodal marginal zone, Primary cutaneous marginal zone lymphoma)Classic Hodgkin's lymphoma (Nodular sclerosis) · CD20 (Nodular lymphocyte predominant Hodgkin's lymphoma)see immunoproliferative immunoglobulin disordersBy infectionDiffuse large B-cell lymphoma · Intravascular large B-cell lymphoma · Primary cutaneous marginal zone lymphoma · Primary cutaneous immunocytoma · Plasmacytoma · Plasmacytosis · Primary cutaneous follicular lymphomaBy development/
markerTdT+: ALL (Precursor T acute lymphoblastic leukemia/lymphoma)
prolymphocyte (Prolymphocytic)
CD30+ (Anaplastic large-cell lymphoma, Lymphomatoid papulosis type A)indolent: Mycosis fungoides · Pagetoid reticulosis · Granulomatous slack skin
aggressive: Sézary's disease · Adult T-cell leukemia/lymphomaNon-MFCD30-: Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma · Pleomorphic T-cell lymphoma · Lymphomatoid papulosis type B
CD30+: CD30+ cutaneous T-cell lymphoma · Secondary cutaneous CD30+ large cell lymphoma · Lymphomatoid papulosis type AOther peripheralHepatosplenic · Angioimmunoblastic · Enteropathy-associated T-cell lymphoma · Peripheral T-cell lymphoma-Not-Otherwise-Specified (Lennert lymphoma) · Subcutaneous T-cell lymphomaBy infectionHTLV-1 (Adult T-cell leukemia/lymphoma)NK cell/
(most CD56)Aggressive NK-cell leukemia · Blastic NK cell lymphomaT or NKLymphoid+myeloidCutaneous lymphoid hyperplasia Cutaneous lymphoid hyperplasia with bandlike and perivascular patterns · Cutaneous lymphoid hyperplasia with nodular pattern · Jessner lymphocytic infiltrate of the skinCategories:- Histopathology
- Lymphoma
- Disease stubs
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