Classification and external resources
ICD-10 D80.0-D80.1
ICD-9 279.00
DiseasesDB 6426
MedlinePlus 001307
eMedicine med/1120 ped/54
MeSH D000361

Hypogammaglobulinemia is a type of immune disorder characterized by a reduction in all types of gamma globulins.[1]

Hypogammaglobulinemia is a characteristic of common variable immunodeficiency.[2]



"Hypogammaglobulinemia" is distinguished from dysgammaglobulinemia, which is a reduction in some types of gamma globulins, but not others.[3][4]

"Hypogammaglobulinemia" is largely synonymous with "agammaglobulinemia". When this term is used (as in "X-linked agammaglobulinemia") it implies that gamma globulins are not merely reduced, but completely absent. Modern assays have allowed most agammaglobulinemias to be more precisely defined as hypogammaglobulinemias,[5] but the distinction is not usually clinically relevant.


Type OMIM Gene
AGM1 601495 IGHM
AGM2 613500 IGLL1
AGM3 613501 CD79A
AGM4 613502 BLNK
AGM5 613506 LRRC8A
AGM6 612692 CD79B


  1. ^ "hypogammaglobulinemia" at Dorland's Medical Dictionary
  2. ^ "common variable immunodeficiency" at Dorland's Medical Dictionary
  3. ^ "Dysgammaglobulinemia" at Dorland's Medical Dictionary
  4. ^ Dysgammaglobulinemia at eMedicine Dictionary
  5. ^ "agammaglobulinemia" at Dorland's Medical Dictionary

External links

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  • hypogammaglobulinemia — noun A type of immune disorder characterised by a reduction in all types of gamma globulins …   Wiktionary

  • hypogammaglobulinemia — Decreased quantity of the gamma fraction of serum globulin; sometimes used loosely to denote decreased quantity of immunoglobulins in general; associated with increased susceptibility to pyogenic infections. SYN: hypogammaglobinemia. acquired h.… …   Medical dictionary

  • hypogammaglobulinemia — hy·po·gam·ma·glob·u·li·ne·mia …   English syllables

  • hypogammaglobulinemia — A condition in which the level of immunoglobulins (antibodies) in the blood is low and the risk of infection is high …   English dictionary of cancer terms

  • hypogammaglobulinemia — noun an abnormally low concentration of gamma globulin in the blood and increased risk of infection • Hypernyms: ↑immunodeficiency …   Useful english dictionary

  • Transient hypogammaglobulinemia of infancy — Infobox Disease Name = PAGENAME Caption = DiseasesDB = ICD10 = ICD10|D|80|7|d|80 ICD9 = ICD9|279.09 ICDO = OMIM = MedlinePlus = eMedicineSubj = ped eMedicineTopic = 2280 MeshID = Transient hypogammaglobulinemia of infancy is a form of… …   Wikipedia

  • physiologic hypogammaglobulinemia — a normal period of hypogammaglobulinemia seen in all infants at about 5–6 months of age as the level of transplacentally acquired maternal immunoglobulins declines before endogenous immunoglobulin synthesis rises to normal levels …   Medical dictionary

  • transient hypogammaglobulinemia of infancy — prolongation of the normal physiologic hypogammaglobulinemia of infancy caused by delayed development of endogenous immunoglobulin production and associated with increased susceptibility to infections …   Medical dictionary

  • X-linked hypogammaglobulinemia — X linked infantile hypogammaglobulinemia see under agammaglobulinemia …   Medical dictionary

  • acquired hypogammaglobulinemia — common variable immunodeficiency …   Medical dictionary

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