Immunodeficiency

Immunodeficiency

Infobox_Disease
Name = Immunodeficiency


Caption =
DiseasesDB = 21506
ICD10 = ICD10|D|84|9|d|80
ICD9 = ICD9|279.3
ICDO =
OMIM =
MedlinePlus =
eMedicineSubj =
eMedicineTopic =
MeshID = D007153
In medicine, immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent. Most cases of immunodeficiency are acquired ("secondary") but some people are born with defects in the immune system, or primary immunodeficiency. Transplant patients take medications to suppress their immune system as an anti-rejection measure, as do some patients suffering from an over-active immune system. A person who has an immunodeficiency of any kind is said to be immunocompromised. An immunocompromised person may be particularly vulnerable to opportunistic infections, in addition to normal infections that could affect everyone.

Types

Primary immunodeficiency

A number of rare diseases feature a heightened susceptibility to infections from childhood onward. Many of these disorders are hereditary and are autosomal recessive or X-linked. There are over 80 recognised primary immunodeficiency syndromes; they are generally grouped by the part of the immune system that is malfunctioning, such as lymphocytes or granulocytes. [cite journal |author=Rosen FS, Cooper MD, Wedgwood RJ |title=The primary immunodeficiencies |journal=N. Engl. J. Med. |volume=333 |issue=7 |pages=431–40 |year=1995 |pmid=7616993|doi=10.1056/NEJM199508173330707]

The treatment of primary immunodeficiencies depends on the nature of the defect, and may involve antibody infusions, long-term antibiotics and (in certain cases) stem cell transplantation.

Acquired immunodeficiency

Immune deficiency may also be the result of particular external processes or diseases; the resultant state is called "secondary" or "acquired" immunodeficiency. Common causes for secondary immunodeficiency are malnutrition, aging and particular medications (e.g. chemotherapy, disease-modifying antirheumatic drugs, immunosuppressive drugs after organ transplants, glucocorticoids).

Many specific diseases directly or indirectly impair the immune system. This includes many types of cancer, particularly those of the bone marrow and blood cells (leukemia, lymphoma, multiple myeloma), and certain chronic infections. Immunodeficiency is also the hallmark of acquired immunodeficiency syndrome (AIDS), caused by the human immunodeficiency virus (HIV). HIV directly attacks the immune system.

References


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Look at other dictionaries:

  • immunodeficiency — 1969, from comb. form of IMMUNE (Cf. immune) + DEFICIENCY (Cf. deficiency) …   Etymology dictionary

  • immunodeficiency — ► NOUN ▪ reduced ability of the immune system to protect the body from infection …   English terms dictionary

  • immunodeficiency — [im΄yə nō′dē fish′ən sē, i′myo͞o΄nōdē fish′ən sē] n. a condition in which the ability of the immune system to produce antibodies is impaired …   English World dictionary

  • immunodeficiency — A condition resulting from a defective immune mechanism; may be primary (due to a defect in the immune mechanism itself) or secondary (dependent upon another disease process), specific (due to a defect in either the B lymphocyte or the T… …   Medical dictionary

  • immunodeficiency — immunodeficient, adj. /im yeuh noh di fish euhn see, i myooh /, n., pl. immunodeficiencies. impairment of the immune response, predisposing to infection and certain malignancies. [1970 75; IMMUNO + DEFICIENCY] * * * Defect in immunity that… …   Universalium

  • immunodeficiency — n. deficiency in the immune response. This can be acquired, as in AIDS, but there are many varieties of primary immunodeficiency occurring as inherited disorders characterized by hypogammaglobulinaemia or defects in T cell function, or both …   The new mediacal dictionary

  • immunodeficiency with elevated IgM — immunodeficiency with hyper IgM a rare syndrome characterized by elevated immunoglobulin M levels and decreased levels of G and A immunoglobulins, associated with recurrent pyogenic infections, and possibly caused by failure of IgM producing… …   Medical dictionary

  • immunodeficiency with thymoma — an immunodeficiency disorder in which thymoma, usually of the benign spindle cell type, is associated with hypogammaglobulinemia; deficiencies of cell mediated immunity, such as eosinopenia, hypoplastic or aplastic anemia, or autoimmune diseases …   Medical dictionary

  • immunodeficiency with short-limbed dwarfism — short limbed dwarfism marked by short, pudgy hands, redundant skin, and hyperextensible joints of the hands and feet associated with immunodeficiency, which may be either antibody or cellular or combined …   Medical dictionary

  • immunodeficiency — noun Date: 1969 inability to produce a normal complement of antibodies or immunologically sensitized T cells especially in response to specific antigens • immunodeficient adjective …   New Collegiate Dictionary

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