D-amino acid dehydrogenase

D-amino-acid dehydrogenase (EC 1.4.99.1) is a bacterial enzyme that catalyses the oxidation of D-amino acids into their corresponding oxoacids. It contains both flavin and nonheme iron as cofactors.^[1] The enzyme has a very broad specificity and can act on most D-amino acids.^[2]

D-amino acid + H₂O + acceptor <=> a 2-oxo acid + NH₃ + reduced acceptor

This reaction is distinct from the oxidation reaction catalysed by D-amino acid oxidase that uses oxygen as a second substrate, as the dehydrogenase can use many different compounds as electron acceptors, with the physiological substrate being coenzyme Q.^[1][3]

See also

• Oxidative phosphorylation
• Electron transport chain
• Microbial metabolism

References

1. ^ ^{a b} Olsiewski PJ, Kaczorowski GJ, Walsh C (25 May 1980). "Purification and properties of D-amino acid dehydrogenase, an inducible membrane-bound iron-sulfur flavoenzyme from Escherichia coli B". J. Biol. Chem. 255 (10): 4487–94. PMID 6102989. http://www.jbc.org/cgi/reprint/255/10/4487. 
2. ^ Tsukada K (10 October 1966). "D-amino acid dehydrogenases of Pseudomonas fluorescens". J. Biol. Chem. 241 (19): 4522–8. PMID 5925166. http://www.jbc.org/cgi/reprint/241/19/4522. 
3. ^ Jones H, Venables WA (1983). "Effects of solubilisation on some properties of the membrane-bound respiratory enzyme D-amino acid dehydrogenase of Escherichia coli". FEBS Lett. 151 (2): 189–92. doi:10.1016/0014-5793(83)80066-0. PMID 6131836. 

External links

• BRENDA entry on EC 1.4.99.1
• ENZYME entry on EC 1.4.99.1

This enzyme-related article is a stub. You can help Wikipedia by expanding it.v ·

This article about metabolism is a stub. You can help Wikipedia by expanding it.v · Categories: Cellular respiration Metabolism EC 1.4 Enzyme stubs Biochemistry stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно решить контрольную? Anna Mariya Urajevskaya Ligusticum apiifolium Look at other dictionaries: L-amino-acid dehydrogenase — In enzymology, a L amino acid dehydrogenase (EC number|1.4.1.5) is an enzyme that catalyzes the chemical reaction:an L amino acid + H2O + NAD+ ightleftharpoons a 2 oxo acid + NH3 + NADH + H+The 3 substrates of this enzyme are L amino acid, H2O,… …   Wikipedia Amino acid oxidoreductases — are oxidoreductases, a type of enzyme, that act upon amino acids.They constitute the majority of enzymes classified under EC number 1.4, with most of the remainder being monoamine oxidases.Examples include: * Glutamate dehydrogenase * Nitric… …   Wikipedia Amino acid — This article is about the class of chemicals. For the structures and properties of the standard proteinogenic amino acids, see Proteinogenic amino acid. The generic structure of an alpha amino acid in its unionized form …   Wikipedia Amino acid — One of the 20 building blocks of protein. The sequence of amino acids in a protein and, hence, the function of that protein are determined by the genetic code in the DNA. Amino acids are molecules that (in technical terms) contain a basic amino… …   Medical dictionary Amino acid synthesis — For the non biological synthesis of amino acids see: Strecker amino acid synthesis Amino acid synthesis is the set of biochemical processes (metabolic pathways) by which the various amino acids are produced from other compounds. The substrates… …   Wikipedia D-amino acid oxidase — Identifiers EC number 1.4.3.3 CAS number 9000 88 8 …   Wikipedia Branched-chain alpha-keto acid dehydrogenase complex — protein Name=2 oxoisovalerate dehydrogenase (lipoamide) caption= width= HGNCid=8523 Symbol=OVD1A AltSymbols= EntrezGene=5014 OMIM= RefSeq= UniProt= PDB= ECnumber=1.2.4.4 Chromosome= Arm= Band= LocusSupplementaryData=The branched chain α keto acid …   Wikipedia branched-chain α-keto acid dehydrogenase complex — a multienzyme complex composed of 3 methyl 2 oxobutanoate dehydrogenase (2 methylpropanoyl transferring) [EC 1.2.4.4] (more commonly called branched chain α keto acid dehydrogenase), dihydrolipoyllysine residue (2 methylpropanoyl)transferase …   Medical dictionary branched-chain α-keto acid dehydrogenase — branched chain α ke·to ac·id de·hy·dro·gen·ase (brancht chān keґto asґid de hiґdro jən ās) an enzyme of the oxidoreductase class that is a component of the multienzyme branched chain α keto acid dehydrogenase complex (q.v …   Medical dictionary Amine dehydrogenase — (EC 1.4.99.3), also known as methylamine dehydrogenase (MADH), is a tryptophan tryptophylquinone dependent (TTQ dependent) enzyme that catalyzes the oxidative deamination of a primary amine to an aldehyde and ammonia. The reaction occurs as… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”