Ethoxzolamide

Ethoxzolamide

Systematic (IUPAC) name
6-ethoxy-1,3-benzothiazole-2-sulfonamide
Clinical data
Pregnancy cat.	?
Legal status	?
Pharmacokinetic data
Protein binding	~89%
Half-life	2.5-5.5 hours
Identifiers
CAS number	452-35-7
ATC code	None
PubChem	CID 3295
DrugBank	APRD00732
ChemSpider	3179 Y
UNII	Z52H4811WX Y
KEGG	D02441 Y
ChEBI	CHEBI:101096 Y
ChEMBL	CHEMBL18 Y
Chemical data
Formula	C9H10N2O3S2
Mol. mass	258.319 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13) Y Key:OUZWUKMCLIBBOG-UHFFFAOYSA-N Y
Y(what is this?)  (verify)

Ethoxzolamide (alternatively known as Ethoxyzolamide) is a sulfonamide medication that functions as a carbonic anhydrase inhibitor. It is used in the treatment of glaucoma, duodenal ulcers, and as a diuretic. It may also be used in the treatment of some forms of epilepsy.

Pharmacology

Ethoxzolamide, a sulfonamide, inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium, potassium, bicarbonate. It also decreases carbonic anhydrase in the CNS, increasing the seizure threshold. This reduction in carbonic anhydrase also reduces the intraocular pressure in the eye by decreasing aqueous humor.

Mechanism of action

Ethoxzolamide binds and inhibits carbonic anhydrase I. Carbonic anhydrase plays an essential role in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space. The inhibition of this enzyme effects the balance of applicable membrane equilibrium systems.