- Ethotoin
drugbox
IUPAC_name = 3-ethyl-5-phenyl-imidazolidine-2,4-dione
width = 201
CAS_number = 86-35-1
ATC_prefix = N03
ATC_suffix = AB01
ATC_supplemental =
PubChem = 3292
DrugBank = APRD00962
C=11 | H=12 | N=2 | O=2
molecular_weight = 204.225 g/mol
bioavailability =
protein_bound =
metabolism =
elimination_half-life = 3 to 9 hours
pregnancy_category = C
legal_status =
routes_of_administration = OralEthotoin (marketed as Peganone by Ovation) is an
anticonvulsant drug used in the treatment ofepilepsy . It is ahydantoin , similar tophenytoin . Ethotoin lacks phenytoin's side effects ofgingiva lhyperplasia andhirsutism , however it is less effective. This, combined with the need for frequent dosing has limited its usefulness. Ethotoin is no longer widely used.Mechanism of action
Similar to phenytoin.
Approval history
*1957 Peganone was granted
Food and Drug Administration (FDA) approval toAbbott Laboratories for treatment of grand mal (tonic clonic) and partial complex (psychomotor) seizures.
*2003 Peganone was acquired from Abbott Laboratories by Ovation Pharmaceuticals (specialty pharmaceutical company who acquire underpromoted branded pharmaceutical products).Indications and usage
Ethotoin is indicated for tonic-clonic and partial complex seizures.
Dosing
Ethotoin is available in 250mg tablets. It is taken orally in 4 to 6 divided doses per day, preferably after food.
ide effects
Ataxia , visual disturbances, rash and gastrointestinal problems.References
* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=13317788&query_hl=10 Peganone, a new antiepileptic drug.] : Dis Nerv Syst. 1956 May;17(5):155-8.: Schwade ED, Richards RK, Everett GM. PMID 13317788
*"The Treatment of Epilepsy" edited by S. D. Shorvon, David R. Fish, Emilio Perucca, W. Edwin Dodson. Blackwell Publishing. 2004. ISBN 0-632-06046-8
* [http://www.drugs.com/pdr/ETHOTOIN.html Drugs.com: Ethotoin]
* [http://ovationpharmaceuticals.com/images/products/pdf/peganone_pi.pdf PEGANONE 250 mg Ethotoin Tablets, USP] (PDF)External links
* [http://www.ovationpharma.com/ Ovation Pharmaceuticals]
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