Mesuximide

Mesuximide
Mesuximide
Systematic (IUPAC) name
(RS)-1,3-dimethyl-3-phenyl-pyrrolidine-2,5-dione
Clinical data
AHFS/Drugs.com Consumer Drug Information
MedlinePlus a682028
Pregnancy cat. C(US)
Legal status ℞-only (US)
Routes Oral
Pharmacokinetic data
Metabolism Hepatic (demethylation and glucuronidation)
Half-life 1.4–2.6 hours (mesuximide)
28–38 hours (active metabolite)
Excretion Renal
Identifiers
CAS number 77-41-8 YesY
ATC code N03AD03
PubChem CID 6476
DrugBank DB05246
ChemSpider 6231 YesY
UNII 0G76K8X6C0 YesY
KEGG D00404 YesY
ChEMBL CHEMBL697 YesY
Chemical data
Formula C12H13NO2 
Mol. mass 203.237 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Mesuximide (or methsuximide) is an succinimide anticonvulsant medication. It is sold as a racemate by Pfizer under the tradenames Petinutin (Switzerland)[1] and Celontin (United States).[2] The therapeutic efficacy of methsuximide is largely due to its pharmacologically active metabolite, N-desmethylmethsuximide, which has a longer half-life and attains much higher plasma levels than its parent.[3]

References

  1. ^ Pfizer AG (2005). "Petinutin (Mésuximide)" (in French). Official Pfizer AG Website. http://www.pfizer.ch/internet/fr/home/products/central_nervous_system/epilepsy/petinutin_mesuximid.html. Retrieved August 21, 2006. [dead link]
  2. ^ Pfizer Inc. (2008). "Celontin (methsuximide capsules, USP)". Official Pfizer Inc. Website. http://www.pfizer.com/products/rx/rx_product_celontin.jsp. Retrieved June 10, 2008. 
  3. ^ Porter RJ, Penry JK, Lacy JR, Newmark ME, Kupferberg HJ. Plasma concentrations of phensuximide, methsuximide, and their metabolites in relation to clinical efficacy. Neurology 29: 1509-1513, 1979.
v · d · eAnticonvulsants (N03)
GABAA receptor agonist
Other GABA agents
Carbonic anhydrase inhibitor
Channel blockers
Primarily sodium
Carbamazepine# • Eslicarbazepine acetate • Oxcarbazepine • Oxitriptyline • Rufinamide
Primarily calcium
Ethosuximide# • Mesuximide • Phensuximide
Unknown/ungrouped
Channel openers
Potassium
Retigabine
Indirect GABA agents

GABA transaminase inhibitor: Valproic acid# (Sodium valproate & Valproate semisodium) • Valpromide • Valnoctamide • Valproate pivoxil

GABA reuptake inhibitor: Tiagabine
Gabapentin • Pregabalin • Progabide • Tolgabide • Vigabatrin
Unknown/multiple/
unsorted
Propionates
#WHO-EM. ‡Withdrawn from market. Clinical trials: †Phase III. §Never to phase III

M: CNS

anat(n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp

noco(m/d/e/h/v/s)/cong/tumr, sysi/epon, injr

proc, drug(N1A/2AB/C/3/4/7A/B/C/D)


Stub icon This anticonvulsant-related article is a stub. You can help Wikipedia by expanding it.