DnaJ (Hsp40) homolog, subfamily C, member 6

PDB rendering based on 1n4c.
Symbols DNAJC6; DJC6; KIAA0473; MGC129914; MGC129915; MGC48436
External IDs OMIM608375 MGI1919935 HomoloGene8865 GeneCards: DNAJC6 Gene
EC number
Species Human Mouse
Entrez 9829 72685
Ensembl ENSG00000116675 ENSMUSG00000028528
UniProt O75061 Q80TZ3
RefSeq (mRNA) NM_014787 NM_198412
RefSeq (protein) NP_055602 NP_940804
Location (UCSC) Chr 1:
65.71 – 65.88 Mb
Chr 4:
101.17 – 101.32 Mb
PubMed search [1] [2]

Putative tyrosine-protein phosphatase auxilin is an enzyme that in humans is encoded by the DNAJC6 gene.[1][2][3]

DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc-finger domain (Ohtsuka and Hata, 2000).[supplied by OMIM][3]


  1. ^ Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Feb 1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484. 
  2. ^ Ohtsuka K, Hata M (Jan 2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress Chaperones 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:MHDHCO>2.0.CO;2. PMC 312896. PMID 11147971. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=312896. 
  3. ^ a b "Entrez Gene: DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9829. 

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