UBE2B

Ubiquitin-conjugating enzyme E2B (RAD6 homolog), also known as UBE2B, is a human gene.cite web | title = Entrez Gene: UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7320| accessdate = ]

PBB_Summary
section_title =
summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.cite web | title = Entrez Gene: UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7320| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Koken MH, Smit EM, Jaspers-Dekker I, "et al." |title=Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31. |journal=Genomics |volume=12 |issue= 3 |pages= 447–53 |year= 1992 |pmid= 1559696 |doi=
*cite journal | author=Koken MH, Reynolds P, Jaspers-Dekker I, "et al." |title=Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 20 |pages= 8865–9 |year= 1991 |pmid= 1717990 |doi=
*cite journal | author=Woffendin C, Chen ZY, Staskus K, "et al." |title=Mammalian mRNAs encoding protein closely related to ubiquitin-conjugating enzyme encoded by yeast DNA repair gene RAD6. |journal=Biochim. Biophys. Acta |volume=1090 |issue= 1 |pages= 81–5 |year= 1991 |pmid= 1883845 |doi=
*cite journal | author=Schneider R, Eckerskorn C, Lottspeich F, Schweiger M |title=The human ubiquitin carrier protein E2(Mr = 17,000) is homologous to the yeast DNA repair gene RAD6. |journal=EMBO J. |volume=9 |issue= 5 |pages= 1431–5 |year= 1990 |pmid= 2158443 |doi=
*cite journal | author=Koken MH, Hoogerbrugge JW, Jasper-Dekker I, "et al." |title=Expression of the ubiquitin-conjugating DNA repair enzymes HHR6A and B suggests a role in spermatogenesis and chromatin modification. |journal=Dev. Biol. |volume=173 |issue= 1 |pages= 119–32 |year= 1996 |pmid= 8575614 |doi=
*cite journal | author=Tateishi S, Sakuraba Y, Masuyama S, "et al." |title=Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 14 |pages= 7927–32 |year= 2000 |pmid= 10884424 |doi=
*cite journal | author=Xin H, Lin W, Sumanasekera W, "et al." |title=The human RAD18 gene product interacts with HHR6A and HHR6B. |journal=Nucleic Acids Res. |volume=28 |issue= 14 |pages= 2847–54 |year= 2000 |pmid= 10908344 |doi=
*cite journal | author=Miura T, Klaus W, Ross A, "et al." |title=The NMR structure of the class I human ubiquitin-conjugating enzyme 2b. |journal=J. Biomol. NMR |volume=22 |issue= 1 |pages= 89–92 |year= 2003 |pmid= 11885984 |doi=
*cite journal | author=Shekhar MP, Lyakhovich A, Visscher DW, "et al." |title=Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitosis, aneuploidy, and transformation. |journal=Cancer Res. |volume=62 |issue= 7 |pages= 2115–24 |year= 2002 |pmid= 11929833 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kwon YT, Xia Z, An JY, "et al." |title=Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway. |journal=Mol. Cell. Biol. |volume=23 |issue= 22 |pages= 8255–71 |year= 2003 |pmid= 14585983 |doi=
*cite journal | author=Lyakhovich A, Shekhar MP |title=RAD6B overexpression confers chemoresistance: RAD6 expression during cell cycle and its redistribution to chromatin during DNA damage-induced response. |journal=Oncogene |volume=23 |issue= 17 |pages= 3097–106 |year= 2004 |pmid= 14981545 |doi= 10.1038/sj.onc.1207449
*cite journal | author=Watanabe K, Tateishi S, Kawasuji M, "et al." |title=Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination. |journal=EMBO J. |volume=23 |issue= 19 |pages= 3886–96 |year= 2005 |pmid= 15359278 |doi= 10.1038/sj.emboj.7600383
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029
*cite journal | author=Shekhar MP, Tait L, Gerard B |title=Essential role of T-cell factor/beta-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells. |journal=Mol. Cancer Res. |volume=4 |issue= 10 |pages= 729–45 |year= 2007 |pmid= 17050667 |doi= 10.1158/1541-7786.MCR-06-0136

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