UBE2D2

Ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast), also known as UBE2D2, is a human gene.cite web | title = Entrez Gene: UBE2D2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7322| accessdate = ]

PBB_Summary
section_title =
summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.cite web | title = Entrez Gene: UBE2D2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7322| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Rolfe M, Beer-Romero P, Glass S, "et al." |title=Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 8 |pages= 3264–8 |year= 1995 |pmid= 7724550 |doi=
*cite journal | author=Scheffner M, Huibregtse JM, Howley PM |title=Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 19 |pages= 8797–801 |year= 1994 |pmid= 8090726 |doi=
*cite journal | author=Jensen JP, Bates PW, Yang M, "et al." |title=Identification of a family of closely related human ubiquitin conjugating enzymes. |journal=J. Biol. Chem. |volume=270 |issue= 51 |pages= 30408–14 |year= 1996 |pmid= 8530467 |doi=
*cite journal | author=Hatakeyama S, Jensen JP, Weissman AM |title=Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases. |journal=J. Biol. Chem. |volume=272 |issue= 24 |pages= 15085–92 |year= 1997 |pmid= 9182527 |doi=
*cite journal | author=Anan T, Nagata Y, Koga H, "et al." |title=Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. |journal=Genes Cells |volume=3 |issue= 11 |pages= 751–63 |year= 1999 |pmid= 9990509 |doi=
*cite journal | author=Gonen H, Bercovich B, Orian A, "et al." |title=Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha. |journal=J. Biol. Chem. |volume=274 |issue= 21 |pages= 14823–30 |year= 1999 |pmid= 10329681 |doi=
*cite journal | author=Joazeiro CA, Wing SS, Huang H, "et al." |title=The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. |journal=Science |volume=286 |issue= 5438 |pages= 309–12 |year= 1999 |pmid= 10514377 |doi=
*cite journal | author=Tongaonkar P, Chen L, Lambertson D, "et al." |title=Evidence for an interaction between ubiquitin-conjugating enzymes and the 26S proteasome. |journal=Mol. Cell. Biol. |volume=20 |issue= 13 |pages= 4691–8 |year= 2000 |pmid= 10848595 |doi=
*cite journal | author=Strack P, Caligiuri M, Pelletier M, "et al." |title=SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4. |journal=Oncogene |volume=19 |issue= 31 |pages= 3529–36 |year= 2000 |pmid= 10918611 |doi= 10.1038/sj.onc.1203647
*cite journal | author=Fang S, Ferrone M, Yang C, "et al." |title=The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 25 |pages= 14422–7 |year= 2002 |pmid= 11724934 |doi= 10.1073/pnas.251401598
*cite journal | author=Yu P, Chen Y, Tagle DA, Cai T |title=PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain. |journal=Genomics |volume=79 |issue= 6 |pages= 869–74 |year= 2002 |pmid= 12036302 |doi= 10.1006/geno.2002.6770
*cite journal | author=Xia Y, Pao GM, Chen HW, "et al." |title=Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. |journal=J. Biol. Chem. |volume=278 |issue= 7 |pages= 5255–63 |year= 2003 |pmid= 12431996 |doi= 10.1074/jbc.M204591200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Takeyama K, Aguiar RC, Gu L, "et al." |title=The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. |journal=J. Biol. Chem. |volume=278 |issue= 24 |pages= 21930–7 |year= 2003 |pmid= 12670957 |doi= 10.1074/jbc.M301157200
*cite journal | author=Xu L, Yang L, Moitra PK, "et al." |title=BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. |journal=Exp. Cell Res. |volume=288 |issue= 1 |pages= 84–93 |year= 2003 |pmid= 12878161 |doi=
*cite journal | author=Subramaniam V, Li H, Wong M, "et al." |title=The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. |journal=Br. J. Cancer |volume=89 |issue= 8 |pages= 1538–44 |year= 2003 |pmid= 14562029 |doi= 10.1038/sj.bjc.6601301
*cite journal | author=Shimura H, Schwartz D, Gygi SP, Kosik KS |title=CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4869–76 |year= 2004 |pmid= 14612456 |doi= 10.1074/jbc.M305838200
*cite journal | author=Lehner B, Semple JI, Brown SE, "et al." |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Winkler GS, Albert TK, Dominguez C, "et al." |title=An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair. |journal=J. Mol. Biol. |volume=337 |issue= 1 |pages= 157–65 |year= 2004 |pmid= 15001359 |doi= 10.1016/j.jmb.2004.01.031

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes