DNAJC1

DnaJ (Hsp40) homolog, subfamily C, member 1
PDB rendering based on 2cqq.
Available structures PDB 2CQQ, 2CQR
Identifiers
Symbols	DNAJC1; DNAJL1; ERdj1; HTJ1; MGC131954; MTJ1
External IDs	OMIM: 611207 MGI: 103268 HomoloGene: 7293 GeneCards: DNAJC1 Gene
Gene Ontology Molecular function • ATPase activator activity • DNA binding • protein binding • heat shock protein binding • unfolded protein binding • chaperone binding Cellular component • nucleus • endoplasmic reticulum • endoplasmic reticulum • endoplasmic reticulum membrane • microsome • membrane • integral to membrane • nuclear membrane Biological process • regulation of transcription, DNA-dependent • regulation of translation • protein folding • positive regulation of ATPase activity • negative regulation of proteolysis • regulation of protein secretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64215	13418
Ensembl	ENSG00000136770	ENSMUSG00000026740
UniProt	Q96KC8	Q61712
RefSeq (mRNA)	NM_022365	NM_007869
RefSeq (protein)	NP_071760	NP_031895
Location (UCSC)	Chr 10: 22.05 – 22.29 Mb	Chr 2: 18.12 – 18.31 Mb
PubMed search	[1]	[2]

DnaJ homolog subfamily C member 1 is a protein that in humans is encoded by the DNAJC1 gene.^[1]

Interactions

DNAJC1 has been shown to interact with Alpha 1-antichymotrypsin.^[2]

References

1. ^ "Entrez Gene: DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64215. 
2. ^ Kroczynska, Barbara; Evangelista Christina M, Samant Shalaka S, Elguindi Ebrahim C, Blond Sylvie Y (Mar. 2004). "The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity". J. Biol. Chem. (United States) 279 (12): 11432–43. doi:10.1074/jbc.M310903200. ISSN 0021-9258. PMC 1553221. PMID 14668352. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1553221. 

Further reading

• Kroczynska B, King-Simmons L, Alloza L, et al. (2006). "BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4.". Biochem. Biophys. Res. Commun. 338 (3): 1467–77. doi:10.1016/j.bbrc.2005.10.101. PMID 16271702. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Kroczynska B, Evangelista CM, Samant SS, et al. (2004). "The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity.". J. Biol. Chem. 279 (12): 11432–43. doi:10.1074/jbc.M310903200. PMC 1553221. PMID 14668352. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1553221. 
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Chevalier M, Rhee H, Elguindi EC, Blond SY (2000). "Interaction of murine BiP/GRP78 with the DnaJ homologue MTJ1.". J. Biol. Chem. 275 (26): 19620–7. doi:10.1074/jbc.M001333200. PMC 1534116. PMID 10777498. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1534116.