HSPA1B

protein
name = heat shock 70kDa protein 1B
caption =


width =
HGNCid = 5233
Symbol = HSPA1B
AltSymbols =
EntrezGene = 3304
OMIM = 603012
RefSeq = NM_005346
UniProt = P08107
PDB =
ECnumber =
Chromosome = 6
Arm = p
Band = 21.3
LocusSupplementaryData =

Heat shock 70kDa protein 1B, also known as HSPA1B, is a human gene.cite journal | author = Milner CM, Campbell RD | title = Structure and expression of the three MHC-linked HSP70 genes | journal = Immunogenetics | volume = 32 | issue = 4 | pages = 242–51 | year = 1990 | pmid = 1700760 | url = | issn = ] This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family.cite web | title = Entrez Gene: HSPA1A heat shock 70kDa protein 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch= 3304 | accessdate = ]

Function

In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.cite journal | author = Ito Y, Ando A, Ando H, Ando J, Saijoh Y, Inoko H, Fujimoto H | title = Genomic structure of the spermatid-specific hsp70 homolog gene located in the class III region of the major histocompatibility complex of mouse and man | journal = J. Biochem. | volume = 124 | issue = 2 | pages = 347–53 | year = 1998 | month = August | pmid = 9685725 | url = http://jb.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=9685725 | issn = ]

Disease linkage

Patients with chronic hepatitis B or hepatitis C virus infection who harbor a HSPA1B-1267 single nucleotide polymorphism have a higher risk for developing hepatocellular carcinoma.cite journal | author = Jeng JE, Tsai JF, Chuang LY, Ho MS, Lin ZY, Hsieh MY, Chen SC, Chuang WL, Wang LY, Yu ML, Dai CY, Chang JG | title = Heat shock protein A1B 1267 polymorphism is highly associated with risk and prognosis of hepatocellular carcinoma: a case-control study | journal = Medicine (Baltimore) | volume = 87 | issue = 2 | pages = 87–98 | year = 2008 | month = March | pmid = 18344806 | doi = 10.1097/MD.0b013e31816be95c | url = | issn = ]

ee also

*Heat shock proteins
*Hsp70

References

External links

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